118030-33-4

Basic information

• Product Name: 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one
• Synonyms: 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one
• CAS NO: 118030-33-4
• Molecular Weight: 263.727
• Mol File: 118030-33-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one(118030-33-4)
• EPA Substance Registry System: 1-(4-chlorophenyl)-4-((dimethylamino)methylene)-3-methyl-1H-pyrazol-5(4H)-one(118030-33-4)

Safety Data

• Hazardous Substances Data: 118030-33-4(Hazardous Substances Data)

Upstream product

• 13024-90-3 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 306747-05-7 1-(4-chlorophenyl)-4-(hydroxymethylene)-3-methyl-1H-pyrazol-5(4H)-one 

Relevant articles and documents

Pyrazolone derivatives: Synthesis, anti-inflammatory, analgesic quantitative structure-activity relationship and in vitro studies

Some 1-(4-chlorophenyl or benzenesulfonamide)-2,3- and/or 4-substituted-1H-pyrazol-5(4H)-one derivatives were synthesized and screened for their anti-inflammatory and analgesic activities, in addition to their ulcerogenic liability. They were found to be active as anti-inflammatory and analgesic agents. Compound 6b was found to be the most active as anti-inflammatory agent and compound 9b was found to be the most active one as anti-inflammatory and analgesic agent. On the other hand, cyclooxygenase-1/-2 (COX-1)/COX-2 isozyme selectivity was also done and the tested compounds showed equal inhibition to both isoforms. Moreover, 2D-quantitative structure-activity relationship (QSAR) studies revealed well predictive and statistically significant and cross validated QSAR model that helps to explore some expectedly potent compounds.