118049-92-6Relevant articles and documents
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists
Pinkerton, Anthony B.,Huang, Dehua,Cube, Rowena V.,Hutchinson, John H.,Struthers, Mary,Ayala, Julia M.,Vicario, Pasquale P.,Patel, Sima R.,Wisniewski, Thomas,DeMartino, Julie A.,Vernier, Jean-Michel
, p. 807 - 813 (2007/10/03)
We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure-activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50/sub