118058-62-1

Basic information

• Product Name: propyl 4-(acetylamino)benzoate
• Synonyms: propyl 4-(acetylamino)benzoate
• CAS NO: 118058-62-1
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.2524
• Mol File: 118058-62-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: propyl 4-(acetylamino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: propyl 4-(acetylamino)benzoate(118058-62-1)
• EPA Substance Registry System: propyl 4-(acetylamino)benzoate(118058-62-1)

Safety Data

• Hazardous Substances Data: 118058-62-1(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 556-08-1 p-(acetylamino)benzoic acid 

Relevant articles and documents

Specificity of esterases and structure of prodrug esters: Reactivity of various acylated acetaminophen compounds and acetylaminobenzoated compounds

The relative rates of enzymatically catalyzed hydrolysis of various esters of p-acetylaminobenzoic acid (APAB) and variously acylated acetaminophen (APAP) derivatives were measured. Neutral, anionic, and cationic esters were examined. The enzyme sources adopted were rat intestinal homogenate, rat liver homogenate, rat plasma, and a partly purified commercial enzyme. In both APAB and APAP esters, neutral esters were the most sensitive of the enzyme sources examined, and the sensitivity was due to the carbon chain length. The APAP esters were enzymatically more stable than the APAP esters. The relative rates of hydrolysis of these esters varied depending on the enzyme source. The ability of structure recognition was good in rat intestinal homogenate, but weak in rat plasma. These results suggest that ester prodrugs can be designed to cleave preferentially at selected sites along the pathway between absorption and disposition in the body.