1180843-76-8

Basic information

• Product Name: Methyl 2-(2-(5-chloro-2-phenoxyphenyl)-N-MethylacetaMido)acetate
• Synonyms: Methyl 2-(2-(5-chloro-2-phenoxyphenyl)-N-MethylacetaMido)acetate;N-[2-(5-Chloro-2-phenoxyphenyl)acetyl]-N-methyl-glycine methyl ester;Glycine, N-[2-(5-chloro-2-phenoxyphenyl)acetyl]-N-methyl-, methyl ester
• CAS NO: 1180843-76-8
• Molecular Formula: C18H18ClNO4
• Molecular Weight: 347.79282
• Mol File: 1180843-76-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.248±0.06 g/cm3 (20 ºC 760 Torr)
• CAS DataBase Reference: Methyl 2-(2-(5-chloro-2-phenoxyphenyl)-N-MethylacetaMido)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(2-(5-chloro-2-phenoxyphenyl)-N-MethylacetaMido)acetate(1180843-76-8)
• EPA Substance Registry System: Methyl 2-(2-(5-chloro-2-phenoxyphenyl)-N-MethylacetaMido)acetate(1180843-76-8)

Safety Data

• Hazardous Substances Data: 1180843-76-8(Hazardous Substances Data)

Upstream product

• 70958-20-2 5-chloro-2-phenoxyphenylacetic acid 
• 5473-12-1 N-methylglycine methylester 

Downstream Products

• 1162120-35-5 3-(5-chloro-2-phenoxyphenyl)-1-methylpyrrolidine-2,4-dione 
• 1012884-46-6 11-chloro-2-methyl-2,3-dihydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 1180843-77-9 trans-11-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 1180843-77-9 cis-11-chloro-2,3,3a,12btetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one 
• 912355-99-8 trans-8-chloro-10,11-dihydro-11-[(methylamino)methyl]-dibenz[b,f]oxepin-10-carboxylic acid 

Relevant articles and documents

Debottlenecking the Synthesis Route of Asenapine

The discovery synthesis of asenapine that was used for the manufacture of drug substance batches up to 10 kg contained two chemical steps that were major bottlenecks for scale-up. One of these steps involved a magnesium/methanol reduction of an enamide moiety that was severely hampered by safety and efficiency problems. The other step was a laborious chromatography and isomerization cycle that was marked by a poor yield and extremely low throughput The safety issues of the magnesium/methanol reduction could be solved by adding portions of magnesium to a solution of the enamide. In addition, an alternative process for the conversion of the mixture of cis- and trans-lactam into the desired trans-isomer was developed, circumventing the chromatographic separation.