118143-76-3 Usage
Description
(S)-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is a chemical compound that is commonly used in organic chemistry. It is an ester derivative of piperidine-2-carboxylic acid, with a tert-butyl group attached to the carboxylic acid functional group. (S)-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is known for its versatility in the synthesis of various pharmaceuticals and agrochemicals, as well as its potential biological and pharmacological properties, making it a valuable compound in the field of medicinal chemistry.
Uses
Used in Pharmaceutical Industry:
(S)-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a building block for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER serves as a building block for the synthesis of agrochemicals. Its application in this field aids in the development of new pesticides, herbicides, and other agricultural chemicals to improve crop protection and yield.
Used as a Reagent in Organic Reactions:
(S)-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER is utilized as a reagent in various organic reactions. Its presence facilitates specific chemical transformations, making it an essential tool for chemists in conducting research and developing new compounds.
Used as a Precursor to Complex Chemical Compounds:
(S)-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER also serves as a precursor to more complex chemical compounds. Its role in the synthesis of intricate molecules highlights its importance in the field of organic chemistry and the creation of advanced materials.
Used in Medicinal Chemistry Research:
(S)-PIPERIDINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER has been studied for its potential biological and pharmacological properties. Its application in research contributes to the understanding of its therapeutic potential, paving the way for the development of new treatments and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 118143-76-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,1,4 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 118143-76:
(8*1)+(7*1)+(6*8)+(5*1)+(4*4)+(3*3)+(2*7)+(1*6)=113
113 % 10 = 3
So 118143-76-3 is a valid CAS Registry Number.
118143-76-3Relevant articles and documents
Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
Atack, Thomas C.,Raymond, Donald D.,Blomquist, Christa A.,Pasaje, Charisse Flerida,McCarren, Patrick R.,Moroco, Jamie,Befekadu, Henock B.,Robinson, Foxy P.,Pal, Debjani,Esherick, Lisl Y.,Ianari, Alessandra,Niles, Jacquin C.,Sellers, William R.
supporting information, p. 2131 - 2138 (2020/12/17)
FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured parasites. However, due to the highly conserved nature of the binding pockets of FKBPs and the immunosuppressive properties of these drugs, there is a need for compounds that selectively inhibit FKBP35 and lack the undesired side effects. In contrast to human FKBPs, FKBP35 contains a cysteine, C106, adjacent to the rapamycin binding pocket, providing an opportunity to develop targeted covalent inhibitors of Plasmodium FKBP35. Here, we synthesize inhibitors of FKBP35, show that they directly bind FKBP35 in a model cellular setting, selectively covalently modify C106, and exhibit antiplasmodium activity in blood-stage cultured parasites.
Extension of the "ring switch" approach to glutamate antagonists to δ-lactam urethanes
Coe, Diane,Drysdale, Martin,Philps, Oliver,West, Robert,Young, Douglas W.
, p. 2459 - 2472 (2007/10/03)
The versatile "ring switching" approach to antagonists of glutamate receptors has been extended to the use of δ-lactam urethanes. Three different types of δ-lactam urethane aldehydes 17, 26 and 59 have been used successfully in this approach. Altering dia
Synthetic Route to the "Tricarbonyl" Region of FK-506
Egbertson, Melissa,Danishefsky, Samuel J.
, p. 11 - 12 (2007/10/02)
Coupling of a complex lithiodithiane to (S)-tert-butyl N-methoxalylpipecolate leads in three steps to the title substructure.
