1181621-12-4

Basic information

• Product Name: 1-(3-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)ethynyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
• Synonyms: 1-(3-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)ethynyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
• CAS NO: 1181621-12-4
• Molecular Weight: 452.392
• Mol File: 1181621-12-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)ethynyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)ethynyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea(1181621-12-4)
• EPA Substance Registry System: 1-(3-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)ethynyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea(1181621-12-4)

Safety Data

• Hazardous Substances Data: 1181621-12-4(Hazardous Substances Data)

Upstream product

• 20348-09-8 4H-pyrido[3,2-b][1,4]oxazin-3-one 
• 122450-96-8 3-Oxo-3,4-dihydro-2H-1-oxa-4,5-diaza-7-bromo-naphthalene 

Relevant articles and documents

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This invention relates to compounds that inhibit protein kinase activity. More particularly, the invention relates to compounds, compositions, and methods fo inhibiting Ret receptor kinase activity, c-Raf kinase activity and/or VEGF receptor kinase activity. These compounds are alkynes substituted by carbocyclic or heterocyclic rings at both ends with further substitutions thereon. They further show in vivo activity against solid tumor disease models.