20348-09-8

Basic information

• Product Name: 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one
• Synonyms: LABOTEST-BB LT00451615;2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)-ONE;TIMTEC-BB SBB006815;2H-PYRIDO(3,2-B)-1,4-OXAZIN-3(4H)-ONE 95 %;4H-Pyrido[3,2-b][1,4]oxazin-3-one ;3,4-Dihydro-2H-pyrido[3,2-b]-1,4-oxazine-3-one;2,3-dihydro-3-oxo-4H-pyrido[3,2-b]-1,4-oxazine;4H-pyrido[2,3-e][1,4]oxazin-3-one
• CAS NO: 20348-09-8
• Molecular Formula: C₇H₆N₂O₂
• Molecular Weight: 150.13
• EINECS: 243-751-1
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Compounds;C7 and C8;Heterocyclic Building Blocks;Pyridines
• Mol File: 20348-09-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 204-206 °C(lit.)
• Boiling Point: 384.159 °C at 760 mmHg
• Flash Point: 186.133 °C
• Appearance: /
• Density: 1.328g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.06±0.20(Predicted)
• BRN: 1074010
• CAS DataBase Reference: 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one(20348-09-8)
• EPA Substance Registry System: 2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one(20348-09-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 20348-09-8(Hazardous Substances Data)

Usage

Uses

2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one was used in the synthesis of quinazolinbenzoxazine derivatives.

InChI:InChI=1/C7H6N2O2/c10-6-4-11-5-2-1-3-8-7(5)9-6/h1-3H,4H2,(H,8,9,10)

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 1268818-15-0 2-(2-nitropyridin-3-yloxy)acetonitrile 
• 15128-82-2 3-hydroxy-2-nitropyridine 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 
• 93765-24-3 3-Amino-2H-pyrido<3,2-b><1,4>oxazine 
• 93765-23-2 2-Amino-3-cyanomethoxypyridine 
• 93765-25-4 N-(2H-Pyrido<3,2-b><1,4>oxazin-3-yl)aminoacetaldehyde Dimethylacetal 
• 79-04-9 chloroacetyl chloride 
• 96-34-4 methyl chloroacetate 
• 337463-88-4 6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 
• 201230-82-2 carbon monoxide 

Downstream Products

• 34950-70-4 4H,4'H-4,4'-(2-hydroxy-propane-1,3-diyl)-bis-pyrido[3,2-b][1,4]oxazin-3-one 
• 34968-16-6 4-Allyl-2H-pyrido<3,2-b>-1,4-oxazin-3(4H)-on 
• 337463-64-6 6-nitro-4H-pyrido[3,2-b][1,4]oxazin-3-one 
• 1214927-88-4 C₁₄H₁₂N₄O₄ 
• 1214927-80-6 C₁₄H₁₄N₄O₂ 
• 1214928-04-7 C₂₃H₂₀N₄O₅ 
• 1214928-12-7 C₂₂H₁₈N₄O₅ 
• 1181621-12-4 1-(3-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)ethynyl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea 
• 1452561-42-0 benzyl (trans-3-(3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)cyclobutyl)carbamate 
• 1417626-71-1 C₂₀H₃₀N₄O₂ 
• 1417626-79-9 C₂₀H₃₂N₄O 
• 1115389-00-8 C₁₄H₁₁FN₂O₂ 
• 312973-08-3 2-(phenylmethylene)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 
• 20348-31-6 3,4-Dihydro-4-methyl-2H-pyrido<3,2-b>-1,4-oxazin 

Relevant articles and documents

Synthesis, characterisation and crystal structure of a novel pyridyl urea Macrocycle

A novel pyridyl urea based macrocycle has been synthesised and fully characterised including a single crystal X-ray structure determination. The synthetic approach first involves the reaction of benzyloxycarbonylaminopropyl-3-isocyanate with t-butyl 2-[(2-Aminopyridin-3- yl)oxy]acetate resulting in a coupling product. After deprotection of the amine and acid moieties and coupling subsequent coupling in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), a macrocycle is formed. The structures of the compounds were confirmed by mass spectrometry and NMR spectroscopy. The X-ray crystal structure of the macrocycle reveals as expected a non-binding conformation with an intramolecular hydrogen bond between the urea NH and the pyridyl nitrogen.

A 2-amino-thiazole compounds (by machine translation)

The present invention relates to the technical field of pharmaceutical chemistry, particularly relates to a 2-amino thiazole compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)

Short and efficient synthesis of oxazinone-and thiazinone-containing bicyclic heteroaromatic aldehydes

Short and efficient route for the synthesis of oxazinone-and thiazinone-containing bicyclic heteroaromatic aldehydes, which involves the key step of palladium-catalyzed reductive carbonylation, is described. Overall routes for the synthesis of these aldehydes are short, versatile, and scalable with good yields of the product. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]