1181690-72-1

Basic information

• Product Name: (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone
• CAS NO: 1181690-72-1
• Molecular Weight: 237.729
• Mol File: 1181690-72-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone(1181690-72-1)
• EPA Substance Registry System: (R)-1-(8-chloro-1-methyl-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanone(1181690-72-1)

Safety Data

• Hazardous Substances Data: 1181690-72-1(Hazardous Substances Data)

Usage

Uses

N-Acetyl Lorcaserin is an impurity of Lorcaserin (L469890, HCl); a novel selective 5-HT2C-receptor agonist for the treatment of obesity. N-Acetyl Lorcaserin is also used as a reagent in the synthesis of isoquinoline, isoindoline, and benzoazepine amides as therapeutic modulators of the histamine H3 receptor.

Upstream product

• 846589-98-8 Lorcaserin hydrochloride 
• 75-36-5 acetyl chloride 

Relevant articles and documents

MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

Amide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as excessive daytime sleepiness, narcolepsy, shift-work sleep disorder, drowsiness as a side effect from a medication, maintenance of vigilance to aid in the completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like.