118172-65-9Relevant academic research and scientific papers
3, 4-dihydroxyphenylethanol synthesis method
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, (2019/04/02)
An embodiment of the invention discloses a 3, 4-dihydroxyphenylethanol synthesis method which includes the steps: taking a compound I as a raw material to prepare a compound II under the action of a catalyst for standby application; performing reaction on the compound II prepared in the first step and strong acid, and extracting and concentrating a reactant to prepare a compound III; dissolving the compound III in a solvent to perform reaction under the of a catalyst to prepare a compound IV; performing diazo-reaction and acidic hydrolysis on the compound IV to generate 3, 4-dihydroxyphenylethanol. According to the 3, 4-dihydroxyphenylethanol synthesis method, raw materials are moderate in cost, mass production is easily implemented, the purity of the 3, 4-dihydroxyphenylethanol is higherthan 99%, and overall yield can reach 78% or more. The synthesis method is simple in reaction condition, special requirements for devices are omitted, the method is easily implemented in industrial production, and organic solvents can be completely recycled and reused in the whole preparation process.
A photoreactive analogue of the immunosuppressant FTY720
Sun, Chaode,Bittman, Robert
, p. 2200 - 2202 (2007/10/03)
An azido group was incorporated into the immunomodulatory agent FTY720, accomplishing the first synthesis of a photoactivatable analogue of this ligand (2) in 9 steps from 2-(4-hydroxyphenyl)ethanol and in 34% overall yield. The key steps are formation of
