1181770-72-8

Basic information

• Product Name: EMD638683
• Synonyms: EMD638683;3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
• CAS NO: 1181770-72-8
• Molecular Formula: C₁₈H₁₈F₂N₂O₄
• Molecular Weight: 364.3433264
• Mol File: 1181770-72-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 657.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.363±0.06 g/cm3(Predicted)
• Solubility: insoluble in H2O; ≥18.2 mg/mL in DMSO; ≥45.8 mg/mL in EtOH with gentle warming
• PKA: 8.68±0.25(Predicted)
• CAS DataBase Reference: EMD638683(CAS DataBase Reference)
• NIST Chemistry Reference: EMD638683(1181770-72-8)
• EPA Substance Registry System: EMD638683(1181770-72-8)

Safety Data

• Hazardous Substances Data: 1181770-72-8(Hazardous Substances Data)

Usage

General Description

EMD638683, also known as JNJ-63733657, is a potent and selective allosteric inhibitor of MALT1, a protease involved in the NF-κB signaling pathway. EMD638683 has been studied for its potential in treating T-cell lymphomas and autoimmune diseases, as well as for its ability to enhance the efficacy of current cancer therapies. EMD638683 has shown promising results in preclinical studies, demonstrating anti-tumor and anti-inflammatory effects. It is thought to work by blocking the activity of MALT1, which plays a key role in regulating immune responses and promoting inflammation. Overall, EMD638683 shows potential as a targeted therapy for various diseases and may have implications for the development of new treatments in the future.

Upstream product

• 1181770-76-2 2-ethyl-4-methoxy-3-methylbenzoic acid 
• 1181770-80-8 N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-methoxy-3-methylbenzohydrazide 
• 5628-61-5 4-methoxy-2,3-dimethyl-benzoic acid 
• 38998-17-3 2,3-dimethyl-4-methoxybenzaldehyde 
• 208259-37-4 methyl 2-(3,5-difluorophenyl)-2-hydroxyacetate 
• 132741-31-2 S-(+)-3.5-Difluoromandelic Acid 

Downstream Products

• 1184940-47-3 N'-[(R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide 
• 1184940-46-2 N'-[(S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide 

Relevant articles and documents

SGK1 INHIBITORS FOR THE PROPHYLAXIS AND/OR THERAPY OF VIRAL DISEASES AND/OR CARCINOMAS

The present invention relates to a compound of the formula I, Ia and Ib, and its pharmaceutically usable tautomers, salts, stereoisomers and the enantiomers, including mixtures thereof in all ratios. The present invention furthermore also relates to compounds of the formula II for the prophylaxis and/or treatment of viral diseases and/or carcinomas, in which R1, R2 each, independently of one another, denote H, CHO or acetyl, R3, R4, R5, R6, R7, R8, R9, R10, R11 each, independently of one another, denote H, A, OSO2A, Hal, NO2, OR12, N(R12)2, CN, O—COA, —[C(R12)2]nCOOR12, O—[C(R12)2]oCOOR12, SO3H, —[C(R12)2]nAr, —CO—Ar, O—[C(R12)2]nAr, —[C(R12)2]nHet, —[C(R12)2]nC≡CH, O—[C(R12)2]nC≡CH, —[C(R12)2]nCON(R12)2, —[C(R12)2]nCONR12N(R12)2, O—[C(R12)2]nCON(R12)2, O—[C(R12)2]oCONR12N(R12)2, NR12COA, NR12CON(R12)2, NR12SO2A, N(SO2A)2, COR12, S(O)mAr, SO2NR12 or S(O)mA, R3 and R4 together also denote CH═CH—CH═CH, R3 and R4, R7 and R8 or R8 and R9 together also denote alkylene having 3, 4 or 5 C atoms, in which one or two CH2 groups may be replaced by oxygen, A denotes unbranched or branched alkyl having 1-6 C atoms, in which 1-7 H atoms may be replaced by F, or cyclic alkyl having 3-7 C atoms, Ar denotes phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OR12, N(R12)2, NO2, CN, phenyl, CON(R12)2, NR12COA, NR12CON(R12)2, NR12SO2A, COR12, SO2N(R12)2, S(O)mA, —[C(R12)2]n—COOR12 and/or —O[C(R12)2]o—COOR12, Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be mono-, di- or trisubstituted by Hal, A; OR12, N(R12)2, NO2, CN, COOR12, CON(R12)2, NR12COA, NR12SO2A, COR12, SO2NR12, S(O)mA, ═S, ═NR12 and/or ═O (carbonyl oxygen), R12 denotes H or A, Ha1 denotes F, Cl, Br or I, m denotes O, 1 or 2, n denotes O, 1, 2 or 3, o denotes 1, 2 or 3, for the prophylaxis and/or treatment of viral diseases and/or carcinomas, and their pharmaceutically usable tautomers, salts, stereoisomers and the enantiomers, including mixtures thereof in all ratios.