1181965-76-3

Upstream product

• 337909-10-1 1-formyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester 
• 67259-63-6 4-(4-(trifluoromethyl)phenyl)piperidine 
• 88612-71-9 ethyl 4-oxo-4H-quinolizine-3-carboxylate 
• 109-06-8 α-picoline 

Downstream Products

• 1181964-57-7 4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid 
• 1181965-77-4 4-oxo-1-({4-[4-(trifiuoromethyl)phenyl]piperidin-1-yl}methyl)-4H-quinolizine-3-carboxylic acid sodium salt 

Relevant academic research and scientific papers

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series

SAR study of the piperidine moiety in a series of quinolizidinone carboxylic acid M1 positive allosteric modulators was examined. While the SAR was generally flat, compounds were identified with high CNS exposure to warrant additional in vivo evaluation.

QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to compounds of formula (I) (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain