118267-18-8

Basic information

• Product Name: N-DEMETHYLROXITHROMYCIN
• Synonyms: N-DEMETHYLROXITHROMYCIN;(9E)-9-[O-[(2-Methoxyethoxy)Methyl]oxiMe]-N-deMethyl ErythroMycin;(E)-N-DeMethylroxithroMycin;RU 44981;Roxithromycin Impurity F
• CAS NO: 118267-18-8
• Molecular Formula: C40H74N2O15
• Molecular Weight: 823.01996
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 118267-18-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 96-98°C
• Appearance: /
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-DEMETHYLROXITHROMYCIN(CAS DataBase Reference)
• NIST Chemistry Reference: N-DEMETHYLROXITHROMYCIN(118267-18-8)
• EPA Substance Registry System: N-DEMETHYLROXITHROMYCIN(118267-18-8)

Safety Data

• Hazardous Substances Data: 118267-18-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

A metabolite of Roxithromycin (R700850).

Upstream product

• 80214-83-1 roxithromycin 

Relevant articles and documents

MODULATION OF IMMUNE RESPONSES BY ADMINISTRATION OF ROXITHROMYCIN OR ITS DERIVATIVE

Provided are compounds of formula (III) useful for modulation of immune responses, compositions comprising the compounds, and methods of use of such compositions for treating diseases or disorders involving an immune response. In certain embodiments, the compounds are useful for the treatment of diseases or disorders associated with transendothelial migration of T cells and activated T cells, and proinflammatory cytokine production from T cells and macrophages. Diseases or disorders that can be treated include arthritic and rheumatic disorders, such as rheumatoid arthritis.

TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory, and prokinetic agents.