118272-45-0

Upstream product

• 118282-96-5 (1E,7Z)-9-(tert-Butyl-dimethyl-silanyloxy)-3,7-dimethyl-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-1,7-dien-4-yne-3,6-diol 
• 40834-42-2 5-hydroxy-4-methyl-5H-furan-2-one 
• 17974-59-3 (7E)-9-ethynyl-β-ionol 
• 118304-63-5 methyl 9-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-4,7-dihydroxy-3,7-dimethyl-(2Z,8E)-nona-2,8-dien-5-ynoate 
• 118282-96-5 (1E,7E)-9-(tert-Butyl-dimethyl-silanyloxy)-3,7-dimethyl-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-1,7-dien-4-yne-3,6-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 79-77-6 (E)-β-ionone 
• 95286-43-4 ethyl 9-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-3,7-dimethyl-4,7-dihydroxy-(2E,8E)-nona-2,8-dien-5-ynoate 
• 118304-71-5 (2E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,8-dien-5-yne-1,4,7-triol 
• 62054-49-3 ethyl (E)-3-formyl-2-butenoate 
• 96928-85-7 methyl (Z)-3-methyl-4-oxo-2-butenoate 
• 83803-81-0 ethyl (E/Z)-4,4-dimethoxy-3-methylbut-2-enoate 

Downstream Products

• 118304-54-4 tert-butyldimethylsilyl Δ¹³-(Z)-retinyl ether 
• 118353-70-1 tBDMS-retinol 
• 116-31-4 all-trans-Retinal 
• 302-79-4 all-trans-retinoic-acid 
• 68-26-8 RETINOL 

Relevant academic research and scientific papers

Synthesis of New Aromatic Retinoid Analogues by Low-Valent Titanium Induced Reductive Elimination

The low-valent titanium reductive elimination reaction, already applied to the stereospecific synthesis of vitamin A and 13-cis-retinol, was used to prepare several retinoic acid analogues in the all-trans configuration or in the 13-cis configuration.This highly stereospecific trans-diene formation allowed an improved synthesis of the title compounds without any purification of the intermediates before the final stage.

HIGHLY STEREOSELECTIVE SYNTHESIS OF VITAMIN A AND ALL-TRANS RETINOIC ACID BY LOW-VALENT TITANIUM INDUCED REDUCTIVE ELIMINATION

Application of the low-valent Titanium induced reductive elimination gave a new and highly stereoselective approach to vitamin A and all-trans retinoic acid.