118304-60-2

Upstream product

• 119947-82-9 (1E,4Z,7Z)-3,7-Dimethyl-9-triethylsilanyloxy-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-1,4,7-triene-3,6-diol 
• 40834-42-2 5-hydroxy-4-methyl-5H-furan-2-one 
• 994-30-9 triethylsilyl chloride 
• 17974-59-3 (7E)-9-ethynyl-β-ionol 
• 119996-77-9 (2Z,5Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,5,8-triene-1,4,7-triol 
• 96928-85-7 methyl (Z)-3-methyl-4-oxo-2-butenoate 
• 119947-83-0 (2Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,8-dien-5-yne-1,4,7-triol 
• 118304-63-5 methyl 9-(2',6',6'-trimethyl-1'-cyclohexen-1'-yl)-4,7-dihydroxy-3,7-dimethyl-(2Z,8E)-nona-2,8-dien-5-ynoate 
• 118272-49-4 (1E,7Z)-3,7-Dimethyl-9-triethylsilanyloxy-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-1,7-dien-4-yne-3,6-diol 

Downstream Products

• 59699-82-0 ethyl 13-cis-retinoate 
• 472-86-6 13-cis-vitamin A aldehyde 
• 4759-48-2 13-cis-retinoic acid 
• 2052-63-3 2-cis-Vitamin-A 

Relevant academic research and scientific papers

Synthesis of New Aromatic Retinoid Analogues by Low-Valent Titanium Induced Reductive Elimination

The low-valent titanium reductive elimination reaction, already applied to the stereospecific synthesis of vitamin A and 13-cis-retinol, was used to prepare several retinoic acid analogues in the all-trans configuration or in the 13-cis configuration.This highly stereospecific trans-diene formation allowed an improved synthesis of the title compounds without any purification of the intermediates before the final stage.