118352-76-4

Upstream product

• 121-44-8 triethylamine 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 

Downstream Products

• 180475-95-0 C₄₁H₃₉Cl₃N₅O₉P 
• 133471-13-3 (R_P)-N²-isobutyryl-5'-O-(4,4-dimethoxytrityl)-2'-deoxyguanosylyl-(3'->5')-N⁶-benzoyl-3'-O-<1,1-dimethylethyl)dimethylsilyl>-2'-deoxyadenosine 3'-H-phosphonate 
• 133471-13-3 (S_P)-N²-isobutyryl-5'-O-(4,4-dimethoxytrityl)-2'-deoxyguanosylyl-(3'->5')-N⁶-benzoyl-3'-O-<1,1-dimethylethyl)dimethylsilyl>-2'-deoxyadenosine 3'-H-phosphonate 

Relevant academic research and scientific papers

Use of ammonium aryl H-phosphonates in the preparation of nucleoside H-phosphonate building blocks

Ammonium 4-methylphenyl H-phosphonate 4c was used in the conversion of 5'-0-(dimethoxy-trityl)-2'-deoxynucleoside derivatives 6 into the corresponding 3'-H-phosphonates 2, which were isolated in a high state of purity and in high yield.

A Convenient Synthesis of Nucleoside 3'-H-Phosphonate Monoesters Using Triphosgene

A practical method for the preparation of deoxyribonucleoside and ribonucleoside 3'-H-phosphonate monoesters via triphosgene-mediated coupling of nucleosides to phosphonic acid is described.

Studies on aryl H-phosphonates. I. An efficient method for the preparation of deoxyribo- and ribonucleoside 3'-H-phosphonate monoesters by transesterification of diphenyl H-phosphonate

A convenient method for the preparation of deoxyribonucleoside and ribonucleoside 3'-H-phosphonate monoesters via transesterification of diphenyl H-phosphonate with suitable protected nucleosides in pyridine is described.