118353-96-1

Usage

Structural features

Bicyclic compound with a nitrogen atom and a carboxylic acid group

Uses

Organic chemistry and pharmaceutical research, potential applications in drug development or as a building block for other chemical synthesis

Importance

Useful in the synthesis of various bioactive compounds, important target for chemical research

Significance

Furthering knowledge of organic chemistry and drug discovery

Upstream product

• 142-29-0 cyclopentene 
• 852547-04-7 benzyl 2-azabicyclo[3.3.0]octane-3-carboxylate 
• 156473-27-7 (3aR,6aR)-octahydrocyclopentapyrrole 
• 89226-36-8 N-[(1S,2R)-2-(2-Chloro-2-cyano-ethyl)-cyclopentyl]-acetamide 
• 87623-98-1 (2R,3aS,6aR)-1-Acetyl-octahydro-cyclopenta[b]pyrrole-2-carbonitrile 

Downstream Products

• 116404-27-4 octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester 
• 1033766-32-3 1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester 
• 1033766-05-0 N-[3-(4-cyclohexyl-7-hydroxy-5-oxo-2,3,3a,4,5,7a,8,8a-octahydro-1H-3b,4-diaza-cyclopenta[a]inden-6-yl)-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl]methanesulfonamide 
• 1033766-31-2 1-cyclohexylamino-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester 
• 93779-31-8 benzyl (1R^*,3R^*,5R^*)-2-azabicyclo<3.3.0>octane-3-carboxylate 
• 125419-12-7 methyl N-methyl-(1SR,3SR,5SR)-2-azabicyclo<3.3.0>octane-3-carboxylate 

Relevant academic research and scientific papers

SATURATED FUSED [1,2-B] PYRIDAZINONE COMPOUNDS

The invention is directed to saturated fused [1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.

Process for the preparation of monocyclic, bicyclic and tricyclic aminoacids

The invention relates to a process for the preparation of compounds of the formula I STR1 in which R represents hydrogen, alkyl or aralkyl, and R1 to R6 denote identical or different radicals hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, aralkyl or aryl, both being monosubstituted, disubstituted or trisubstituted in the aryl moiety by alkyl, alkoxy, hydroxyl, halogen, nitro, methylenedioxy and/or cyano, or in which two of the radicals R1 to R6, together with the carbon atom(s) bearing them form a monocyclic or bicyclic ring system, and the remaining radicals are hydrogen, which process comprises converting, with an oxidizing agent in the presence of a silver salt, a pyrrolidine derivative of the formula II into a Δ1 -pyrroline derivative of the formula III, reacting the latter with hydrogen cyanide or a metal cyanide to form a nitrile of the formula IV, and subjecting the latter to solvolysis with a compound of the formula ROH.

COUPLING OF β-ACETAMIDO RADICALS WITH α-CHLORO ACRYLONITRILE - A NEW ACCESS TO DISUBSTITUTED PROLINE DERIVATIVES

β-Acetamido radicals are prepared by reduction of organomercurials and coupled with α-chloro-acrylonitrile.The coupling products are further converted to proline derivatives.