118359-33-4 Usage
Uses
Used in Pharmaceutical Applications:
AMinopterin-α-hyrazide is used as a pharmaceutical agent for its ability to inhibit dihydrofolate reductase, a key enzyme in the synthesis of nucleotides and amino acids. This inhibition can disrupt cellular processes and potentially be utilized in the treatment of certain conditions.
Used in Anticancer Applications:
In the field of oncology, AMinopterin-α-hyrazide is used as an anticancer agent. Its inhibition of dihydrofolate reductase can lead to the disruption of nucleotide synthesis, which is essential for cancer cell proliferation. This makes it a candidate for the development of targeted therapies against various types of cancer.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of AMinopterin-α-hyrazide, it can be incorporated into drug delivery systems. These systems can be designed to improve the compound's solubility, stability, and targeted delivery to specific cells or tissues, potentially increasing its therapeutic effects and reducing side effects.
Used in Research Applications:
AMinopterin-α-hyrazide can also be used as a research tool to study the role of dihydrofolate reductase in various biological processes. By understanding how AMinopterin-α-hyrazide interacts with the enzyme, researchers can gain insights into the development of new therapeutic strategies and the fundamental mechanisms underlying certain diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 118359-33-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,3,5 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 118359-33:
(8*1)+(7*1)+(6*8)+(5*3)+(4*5)+(3*9)+(2*3)+(1*3)=134
134 % 10 = 4
So 118359-33-4 is a valid CAS Registry Number.
118359-33-4Relevant academic research and scientific papers
Vlahov, Iontcho R.,You, Fei,Santhapuram, Hari Krishna R.,Wang, Yu,Vaughn, Jeremy F.,Hahn, Spencer J.,Kleindl, Paul J.,Fan, Mingjin,Leamon, Christopher P.
, p. 1202 - 1205 (2011)
Efficient syntheses of folate receptor (FR) targeting conjugates of the anti-inflammatory, aminopterin hydrazide, are described. 2-{4-Benzoylamino}-5- oxo-5-{N′-[2-(pyridin-2-yldisulfanyl)-ethoxycarbonyl]-hydrazino} -pentanoic acid is synthesized from commercially available 4-[(2-amino-4-imino- 3,4-dihydro-pteridin-6-yl-methyl)-amino]-benzoic acid. Conjugation of this novel, activated aminopterin hydrazide to folic acid through cysteine-terminating (C-terminus), peptide/carbohydrate spacers results in highly water soluble conjugates which allow for the release of free aminopterin hydrazide within the endosomes of targeted cells.
