118409-57-7

Basic information

• Product Name: AG 18
• Synonyms: RARECHEM AL BX 0069;RG-50810;TYRPHOSTIN RG 50858;TYRPHOSTIN AG 18;TYRPHOSTIN A23;TYRPHOSTIN 23;ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMONITRILE;AG 18
• CAS NO: 118409-57-7
• Molecular Formula: C₁₀H₆N₂O₂
• Molecular Weight: 186.17
• Product Categories: All Inhibitors;Inhibitors;Tyrosine Kinase Inhibitors;Protein Kinase;Intracellular Signaling
• Mol File: 118409-57-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 225°C
• Boiling Point: 421.1 °C at 760 mmHg
• Flash Point: 208.5 °C
• Appearance: Yellow-tan solid
• Density: 1.428 g/cm³
• Vapor Pressure: 1.09E-07mmHg at 25°C
• Refractive Index: 1.696
• Storage Temp.: 2-8°C
• Solubility: Soluble in DMSO, ethanol, or DMF
• PKA: 7.26±0.18(Predicted)
• Stability: Store in refrigerator
• CAS DataBase Reference: AG 18(CAS DataBase Reference)
• NIST Chemistry Reference: AG 18(118409-57-7)
• EPA Substance Registry System: AG 18(118409-57-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 118409-57-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Powder

Uses

Different sources of media describe the Uses of 118409-57-7 differently. You can refer to the following data:
1. A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM)
2. AG 18 inhibits EGFR with IC50 of 35 μM.
3. A specific inhibitor for the epidermal growth factor receptor. Also inhibits EGF-dependent cell proliferation (IC50=35uM).

Biological Activity

Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC 50 values are 35 and 25 μ M respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

InChI:InChI=1/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

Upstream product

• 110-89-4 piperidine 
• 109-77-3 malononitrile 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 6515-06-6 3,4-bis-methoxymethoxy-benzaldehyde 

Downstream Products

• 122520-85-8 AG 99 

Relevant articles and documents

Synthesis of Polyfunctionalized Pyrroles via Green Chemical Methods

Water was found to be an excellent solvent for the one-pot synthesis of tetrasubstituted pyrrole derivatives under ultrasound involving the standard Knoevenagel condensation followed by the Michael type reaction. A new catalyst free system, excellent atom

Supramolecular polymeric aggregation behavior and its impact on catalytic properties of imidazolium based hydrophilic ionic liquids

Ionic Liquids (ILs) self-assemble to form supramolecular polymeric clusters/aggregates. The aggregation behavior of ILs influences its activity in the organic synthesis. However, the precise role of ILs in organic reactions is still unknown. It is, therefore, important to comprehend the supramolecular polymeric aggregation behavior of ILs. We are exploring the supramolecular polymeric aggregation behavior of ILs using Electrospray Ionization Mass Spectrometry (ESI-MS). We have synthesized four hydrophilic ILs (1–4) and investigated their aggregation behavior and its impact on catalytic activity in Carbon-Carbon bond formation (Knoevenagel and Claisen-Schmidt condensation). Here, we show that the aggregation behavior of ILs depends on the type and nature of cation and anion. ESI-MS (?ve) spectra reveals two different type of aggregation i.e. [CnAn+1]? & [A2 + H+]?. We have found that catalytic activity increases with increased [CnAn+1]? supramolecular aggregation. Consequently, highest yield of products obtained in ILs which show decreased anion-anion aggregation [A2 + H+]? abundance in ESI-MS. We anticipate our results to be a starting point for the establishment of desired ILs for organic synthesis.

Solvatochromism of catechol derivatives - Solute/solvent interactions

The solvatochromism of nine push-pull substituted catechol derivatives has been studied in a set of 39 various solvents. The influence of successive methyl substitution at the catechol OH groups on the extent of the solvatochromic shift has been investiga