118447-04-4

Basic information

• Product Name: (2S)-2-<<<(1S)-1-(methoxycarbonyl)-2-phenylethyl>amino>methyl>pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (2S)-2-<<<(1S)-1-(methoxycarbonyl)-2-phenylethyl>amino>methyl>pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 118447-04-4
• Molecular Weight: 362.469
• Mol File: 118447-04-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S)-2-<<<(1S)-1-(methoxycarbonyl)-2-phenylethyl>amino>methyl>pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-<<<(1S)-1-(methoxycarbonyl)-2-phenylethyl>amino>methyl>pyrrolidine-1-carboxylic acid tert-butyl ester(118447-04-4)
• EPA Substance Registry System: (2S)-2-<<<(1S)-1-(methoxycarbonyl)-2-phenylethyl>amino>methyl>pyrrolidine-1-carboxylic acid tert-butyl ester(118447-04-4)

Safety Data

• Hazardous Substances Data: 118447-04-4(Hazardous Substances Data)

Upstream product

• 69610-41-9 Boc-L-Pro-H 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 115186-37-3 tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 

Downstream Products

• 148138-24-3 (S)-3-phenyl-2-((S)-pyrrolidin-2-ylmethylamino)propanoic acid 
• 1337956-86-1 C₁₉H₂₈N₂O₄ 
• 137282-05-4 (3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid isopropyl ester 
• 137282-35-0 (S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid 
• 137282-34-9 (S)-2-(3-oxohexahydro-3H-pyrrolo<1,2-c>imidazol-2-yl)-3-phenylpropionic acid methyl ester 
• 134161-25-4 (S)-N-<<1-(t-butoxycarbonyl)-2-pyrrolidinyl>-methyl>-N-(benzyloxycarbonyl)phenylalanine 
• 134161-27-6 (S)-N-<<1-(t-butoxycarbonyl)-2-pyrrolidinyl>-methyl>-N-methyl-phenylalanine 
• 134161-27-6 (S)-N-<<1-(t-butoxycarbonyl)-2-pyrrolidinyl>-methyl>-N-methyl-D-phenylalanine 
• 135545-27-6 (S)-2-{[Benzyloxycarbonyl-(1-methoxycarbonyl-2-phenyl-ethyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 135545-29-8 (S)-N-<<1-(t-butoxycarbonyl)-2-pyrrolidinyl>-methyl>-N-methylphenylalanine methyl ester 
• 134161-25-4 (S)-N-<<1-(t-butoxycarbonyl)-2-pyrrolidinyl>-methyl>-N-(benzyloxycarbonyl)-D-phenylalanine 
• 135545-27-6 (S)-2-{[Benzyloxycarbonyl-(1-methoxycarbonyl-2-phenyl-ethyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 135545-29-8 (S)-N-<<1-(t-butoxycarbonyl)-2-pyrrolidinyl>-methyl>-N-methyl-D-phenylalanine methyl ester 
• 137282-33-8 (2S)-2-<<<(1S)-1-(methoxycarbonyl)-2-phenylethyl>amino>methyl>pyrrolidine 

Relevant articles and documents

Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition

A series of novel proline-based reduced dipeptides was developed and evaluated for a direct Michael addition of ketones and aldehydes to nitroalkenes. Excellent yields (up to 95%), diastereoselectivities (up to 98% dr) and enantioselectivities (up to 98%

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF BRADYKININ ANALOGUES WITH Ψ(E,CH=CH) AND Ψ(CH2-NH) ISOSTERIC PEPTIDE BOND REPLACEMENTS

The synthesis of bradykinin analogues is described in which the Gly4-Phe5, Phe5-Ser6 or the Pro7-Phe8 peptide bond has been replaced by a trans carbon-carbon double bond or by a "reduced" peptide bond.Some of the analogues display high potency and prolonged activity in the rat blood pressure test, indicating increased metabolic stability.A clear selectivity is obtained towards the myotropic effect in the guinea pig ileum.