118459-48-6

Usage

Physical state

White solid

Derivative

Malonic acid

Substitution group

4-chlorophenyl

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, building block in organic synthesis (particularly in the formation of heterocyclic compounds)

Potential applications

Materials science (e.g. development of new polymers and supramolecular assemblies)

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 34402-92-1 2-(4-chlorophenyl)malonic acid dimethyl ester 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 1068-55-9 isopropylmagnesium chloride 

Downstream Products

• 874490-30-9 4-(4-chloro-phenyl)-1,2-diphenyl-pyrazolidine-3,5-dione 
• 68823-00-7 (4-chloro-phenyl)-malonyl dichloride 

Relevant academic research and scientific papers

Palladium-Catalyzed Asymmetric Allylic Alkylation of 4-Substituted Isoxazolidin-5-ones: Straightforward Access to β2,2-Amino Acids

We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to β2,2-amino acids bearing an all-carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity.

Organocatalytic Enantioselective Decarboxylative Protonation Reaction of Meldrum's Acid Derivatives under PTC Conditions

An original organocatalyzed enantioselective protonation sequence of a transient quaternary ammonium enolate species has been developed by starting from readily available disubstituted Meldrum's acid derivatives and phenols. Under phase-transfer-catalytic (PTC) conditions, chiral nonracemic 2-aryl propionic ester derivatives were obtained in good isolated yields with enantioselectivities up to 70 % ee. The usefulness of the approach was demonstrated by the synthesis of enantioenriched (S)-ibuprofen.