118459-75-9Relevant academic research and scientific papers
Demonstration of Exclusive α-Peptidation at the Micellar Interface
Ranganathan, Darshan,Ranganathan, Subramania,Singh, Girij Pal,Patel, Bhisma Kumar
, p. 525 - 528 (2007/10/02)
Microreactors, dispersed in iso-octane, harboring water pools and crafted from AOT and co-surfactant condensing agent DODCI, exclusively direct α-peptidation, thus reversing the normal preference of glutamic acid and aspartic acid for side chain carboxyl group amidation.
The Demonstration of Selective Peptide Bond Formation in Clear Aqueous Solutions
Ranganathan, Darshan,Singh, Girij Pal
, p. 142 - 143 (2007/10/02)
The distribution of dipeptides upon treatment of equimolar amounts of glutamic acid, leucine, and C6H11N=C=N(CH2)3+NMe3-OSO2C6H4Me-p, in clear aqueous solution followed by N,C-protection, was found to be: Bz-Glu(γ-OMe)-Leu-OMe (72percent), Bz-Glu(α-OMe)-Glu-di-OMe (15percent), and Bz-Leu-Leu-OMe (8percent); Bz-Leu-Glu-di-OMe, Bz-Glu(α-OMe)-Leu-OMe, and Bz-Glu(γ-OMe)-Glu-di-OMe could not be detected (Bz = PhCO).
