1184912-51-3Relevant articles and documents
Heteroannulation of chromene derivatives. Synthesis of chromeno[4,3-e] indazolone, chromeno4,3-flquinazoline and pyrano[3,2-c]chromene derivatives
Mahmoud, Mahmoud R.,El-Bassiouny, Fakhry A.,Azab, Mohamed E.,El-Kady, Mohamed Y.,Rashed, Hesham M.
experimental part, p. 41 - 45 (2009/09/25)
Pentane-2,4-dione and 3-ethoxycarbonylcoumarin react in the presence of sodium ethoxide to form 10-acetyl-7,9-dihydroxy-6H-benzo[c]chromen-6-one (2). Compound 2 reacted with aromatic aldehydes and ethyl cyanoacetate to give the chromeno-chromenediones 3 and 4 respectively, with hydrazine hydrate to form the azine 5, with phenyl hydrazine giving the chromeno-indazole 6, with primary amines to form the imines 7a-f, and with thiourea to give the chromeno-quinazoline 8. Methyl 2-amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro- pyrano[3,2-c]chromene-3-carboxylate (9a) and the corresponding 3-carbonitrile 9b were prepared, and the reactions of the ester 9a with phenacyl chloride, furoyl chloride, and hydrazine hydrate were investigated.