607697-15-4Relevant academic research and scientific papers
Montmorillonite-KSF mediated one step synthesis of pyranochromene derivatives
Subbareddy, Chitreddy V.,Subashini, Radhakrishnan,Sumathi, Shanmugam
, p. 747 - 754 (2018)
One-pot three-component reaction of substituted aromatic aldehydes, 2-cyanoacetamide and 4-hydroxycoumarin in the presence of Montmorillonite-KSF (MKSF) in ethanol results in the formation of pyrano[3,2-c]chromene-3-carboxylates (5a-m) has been described. The reaction was tested in different alcohols, afforded pyrano [3,2-c] chromene-3-carboxylates (5a-m) of the corresponding alcohols in good yield. The mechanism reveals that the alcohol (as solvent) plays a major role in the inter conversion of amide to the corresponding esters with Montmorillonite KSF (M-KSF) as a catalyst. Excellent yields, inexpensive and readily available substrates, environmentally benign reaction condition, shorter reaction time, and easy workup are the major advantageous features of this protocol.
Heteroannulation of chromene derivatives. Synthesis of chromeno[4,3-e] indazolone, chromeno4,3-flquinazoline and pyrano[3,2-c]chromene derivatives
Mahmoud, Mahmoud R.,El-Bassiouny, Fakhry A.,Azab, Mohamed E.,El-Kady, Mohamed Y.,Rashed, Hesham M.
experimental part, p. 41 - 45 (2009/09/25)
Pentane-2,4-dione and 3-ethoxycarbonylcoumarin react in the presence of sodium ethoxide to form 10-acetyl-7,9-dihydroxy-6H-benzo[c]chromen-6-one (2). Compound 2 reacted with aromatic aldehydes and ethyl cyanoacetate to give the chromeno-chromenediones 3 and 4 respectively, with hydrazine hydrate to form the azine 5, with phenyl hydrazine giving the chromeno-indazole 6, with primary amines to form the imines 7a-f, and with thiourea to give the chromeno-quinazoline 8. Methyl 2-amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro- pyrano[3,2-c]chromene-3-carboxylate (9a) and the corresponding 3-carbonitrile 9b were prepared, and the reactions of the ester 9a with phenacyl chloride, furoyl chloride, and hydrazine hydrate were investigated.
