1184913-64-1

Basic information

• Product Name: 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile
• Synonyms: 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile;1-Hydroxyisoquinoline-7-carbonitrile
• CAS NO: 1184913-64-1
• Molecular Formula: C10H6N2O
• Molecular Weight: 170.16744
• Mol File: 1184913-64-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile(1184913-64-1)
• EPA Substance Registry System: 1-oxo-1,2-dihydroisoquinoline-7-carbonitrile(1184913-64-1)

Safety Data

• Hazardous Substances Data: 1184913-64-1(Hazardous Substances Data)

Usage

General Description

1-oxo-1,2-dihydroisoquinoline-7-carbonitrile is a chemical compound with the molecular formula C11H8N2O. It is a derivative of isoquinoline, which is a heterocyclic aromatic organic compound. The compound contains a nitrile group and a ketone group, and it is often used as a building block in organic synthesis. Its structure and reactivity make it useful in the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. The compound's unique properties and versatile nature make it a valuable tool in the field of organic chemistry.

Upstream product

• 223671-15-6 7-bromo-1(2H)-isoquinolone 

Downstream Products

• 1301214-62-9 1-oxo-2H-isoquinoline-7-carboxylic acid 

Relevant articles and documents

Enantioselective template-directed [2+2] photocycloadditions of isoquinolones: Scope, mechanism and synthetic applications

A strategy for the enantioselective [2+2] photocycloaddition of isoquinolones with alkenes is presented, in which the formation of a supramolecular complex between a chiral template and the substrate ensures high enantioface differentiation by shielding one face of the substrate. Fifteen different electron-deficient alkenes and ten different substituted isoquinolones undergo efficient photocycloaddition, yielding the cyclobutane products in excellent yields and with outstanding regio-, diastereo- and enantioselectivities (up to 990 ee). The mechanism of the reaction is investigated by means of triplet sensitization/quenching and radical clock experiments, the results of which are consistent with the involvement of a triplet excited state and a 1,4-biradical intermediate. The variety of functionalized cyclobutanes obtained using this approach can be further increased by straightforward synthetic transformations of the photoadducts, allowing rapid access to libraries of compounds for various applications.