118492-87-8

Basic information

• Product Name: BOC-CIS-3-HYDROXY-D-PROLINE
• Synonyms: BOC-CIS-3-HYDROXY-D-PROLINE;N-T-BOC-CIS-3-HYDROXY-D-PROLINE;(2R-cis)-3-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester;Boc-(3S)- 3-hydroxy- D-Proline
• CAS NO: 118492-87-8
• Molecular Formula: C₁₀H₁₇NO₅
• Molecular Weight: 231.25
• Mol File: 118492-87-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 101-103 °C
• Boiling Point: 390.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.312
• PKA: 3.69±0.40(Predicted)
• CAS DataBase Reference: BOC-CIS-3-HYDROXY-D-PROLINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-CIS-3-HYDROXY-D-PROLINE(118492-87-8)
• EPA Substance Registry System: BOC-CIS-3-HYDROXY-D-PROLINE(118492-87-8)

Safety Data

• Hazardous Substances Data: 118492-87-8(Hazardous Substances Data)

Usage

Uses

Boc-cis-3-hydroxy-D-proline is a useful research chemical.

Upstream product

• 4298-05-9 cis-3-hydroxy-DL-proline 
• 24608-52-4 tert-butyl chloroformate 
• 118449-01-7 (2R,3S)-3-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 118492-86-7 (+)-cis-(2R,3S)-3-hydroxyproline 
• 146256-97-5 3-(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-propionic acid ethyl ester 
• 170123-25-8 3-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 186132-94-5 (2R,3S)-3-Acetoxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 87125-48-2 cis-N-(tert-butoxycarbonyl)-3-hydroxy-DL-proline 
• 118492-88-9 cis-3-acetoxy-N-(tert-butoxycarbonyl)-D-proline 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 

Downstream Products

• 567-35-1 (2S,3R)-3-hydroxyproline 
• 118492-87-8 (3S)-1-(tert-butoxycarbonyl)-3-hydroxy-D-proline 
• 147214-63-9 cyclothialidine 
• 186132-96-7 (2S,3R)-1-[(tert-butoxy)carbonyl]-3-hydroxypyrrolidine-2-carboxylic acid 
• 186132-95-6 2-benzyl 1-(tert-butyl)(2S,3R)-3-hydroxypyrrolidine-1,2-dicarboxylate 
• 186132-94-5 (2R,3S)-3-Acetoxy-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 87125-58-4 (3aR,7S,7aS)-7-Benzoyloxy-5-oxo-hexahydro-pyrano[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester 
• 87125-58-4 (3aR,7R,7aS)-7-Benzoyloxy-5-oxo-hexahydro-pyrano[3,2-b]pyrrole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Baker's Yeast Reductions of β-Oxopyrrolidinecarboxylates: Synthesis of (+)-cis-(2R,3S)-3-Hydroxyproline and (-)-(1S,5S)-Geissman-Waiss Lactone, a Useful Precursor to Pyrrolizidine Alkaloids

Baker's yeast reduction of the β-oxo proline derivative 5 leads to the cis-hydroxy ester 6 and thence to (+)-cis-(2R,3S)-3-hydroxyproline 7, with >90percent enantiomeric enrichment.Subsequent one-carbon homologation leads to the (-)-Geissman-Waiss lactone

SUBSTITUTED N-(1H-INDAZOL-4-YL)IMIDAZO[1, 2-A]PYRIDINE-3- CARBOXAMIDE COMPOUNDS AS CFMS INHIBITORS

Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.

Synthesis of rac-detoxinine

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