118499-73-3Relevant academic research and scientific papers
Antitumor and anti-Pneumocystis carinii activities of novel bisbenzamidines
Vanden Eynde, Jean Jacques,Mayence, Annie,Johnson, Melissa T.,Huang, Tien L.,Collins, Margaret S.,Rebholz, Sandra,Walzer, Peter D.,Cushion, Melanie T.,Donkor, Isaac O.
, p. 143 - 157 (2005)
Among a library of 17 bisbenzamidines connected with various linkers, compounds with a flexible pentanediamide (10) or hexanediamide (12) linker were the most potent derivatives against rat Pneumocystis carinii (IC50 values of 3 and 2 nM, respe
Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia
Vanden Eynde, Jean Jacques,Mayence, Annie,Huang, Tien L.,Collins, Margaret S.,Rebholz, Sandra,Walzer, Peter D.,Cushion, Melanie T.
, p. 4545 - 4548 (2004)
A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as excep
Antiparasitic Agents: Part VI - Synthesis of 1,2-, 1,3,- and 1,4-Bis(4-substituted aryloxy)benzenes and their Biological Activities
Chauhan, P. M. S.,Niyer, R.,Bhakuni, D. S.,Shankhdhar, V.,Guru, P.Y.,Sen, A. B.
, p. 38 - 42 (2007/10/02)
Several 1,2-, 1,3-, 1,4-bis(4-amidinophenoxy)benzenes (8-10); 1,2-, 1,3-, 1,4-bis(4-amidinobenzyloxy)benzenes (14-16) and 1,2-, 1,3-, 1,4-bis(4-amidinophenoxymethyl)benzenes (26-28) and the corresponding amidoximes (17-19), (29-31) and 33 have been synthe
