Antitumor and anti-Pneumocystis carinii activities of novel bisbenzamidines

DOI: 10.1007/s00044-005-0130-2

Source and publish data:

Medicinal Chemistry Research p. 143 - 157 (2005)

Update date:2022-07-31

Topics:

Authors:

Vanden Eynde, Jean Jacques

Mayence, Annie

Johnson, Melissa T.

Huang, Tien L.

Collins, Margaret S.

Rebholz, Sandra

Walzer, Peter D.

Cushion, Melanie T.

Donkor, Isaac O.

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Article abstract of DOI:10.1007/s00044-005-0130-2

Among a library of 17 bisbenzamidines connected with various linkers, compounds with a flexible pentanediamide (10) or hexanediamide (12) linker were the most potent derivatives against rat Pneumocystis carinii (IC₅₀ values of 3 and 2 nM, respe

Full text of DOI:10.1007/s00044-005-0130-2

Med Chem Res 14:3 (2005) 143–157

௠ Birkha¨user Boston 2005

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Received:

05-27-05

Accepted:

08-22-05

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