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1185035-71-5

BICALUTAMIDE-D4 is a deuterated analog of Bicalutamide, a non-steroidal androgen receptor antagonist. It is a white solid and is used as an internal standard for the quantification of Bicalutamide by GCor LC-MS. Bicalutamide is known for its ability to bind the androgen receptor, preventing its activation and the subsequent upregulation of androgen-responsive genes by androgenic hormones. This property makes BICALUTAMIDE-D4 a valuable tool in examining the role of androgen receptor inactivation in the proliferation of prostate cancer cells and serves as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.

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  • 1185035-71-5 Structure

  • Basic information

    1. Product Name: BICALUTAMIDE-D4
    2. Synonyms: BICALUTAMIDE-D4;Casodex-d4;ICI-176334-d4;N-[4-Cyano-3-trifluoromethyl)phenyl]- 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide-d4;(CI-176334-D4
    3. CAS NO:1185035-71-5
    4. Molecular Formula: C18H10D4F4N2O4S
    5. Molecular Weight: 434.4
    6. EINECS: N/A
    7. Product Categories: Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Sulfur & Selenium Compounds;Isotope Labelled Compounds
    8. Mol File: 1185035-71-5.mol

  • Chemical Properties

    1. Melting Point: 192-1940C
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
    9. CAS DataBase Reference: BICALUTAMIDE-D4(CAS DataBase Reference)
    10. NIST Chemistry Reference: BICALUTAMIDE-D4(1185035-71-5)
    11. EPA Substance Registry System: BICALUTAMIDE-D4(1185035-71-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1185035-71-5(Hazardous Substances Data)

1185035-71-5 Usage

Uses

Used in Pharmaceutical Research:
BICALUTAMIDE-D4 is used as an internal standard for the quantification of Bicalutamide by GCor LC-MS. This application aids in the accurate measurement and analysis of Bicalutamide levels in various samples, which is crucial for research and development in the pharmaceutical industry.
Used in Prostate Cancer Research:
BICALUTAMIDE-D4 is used as an antiandrogen and antineoplastic (hormonal) agent in the study of prostate cancer. Its ability to bind the androgen receptor and prevent its activation helps researchers understand the role of androgen receptor inactivation in the proliferation of prostate cancer cells.
Used in Drug Development:
BICALUTAMIDE-D4 serves as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy. This application is vital in the development of new drugs and therapies targeting androgen-related conditions and diseases.
Used in Analytical Chemistry:
As a deuterated analog, BICALUTAMIDE-D4 is used in analytical chemistry for the accurate quantification and analysis of Bicalutamide. This application is essential for quality control, drug development, and ensuring the safety and efficacy of pharmaceutical products.

Check Digit Verification of cas no

The CAS Registry Mumber 1185035-71-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,5,0,3 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1185035-71:
(9*1)+(8*1)+(7*8)+(6*5)+(5*0)+(4*3)+(3*5)+(2*7)+(1*1)=145
145 % 10 = 5
So 1185035-71-5 is a valid CAS Registry Number.

1185035-71-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)sulfonylpropanamide

1.2 Other means of identification

Product number -
Other names Casodex

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1185035-71-5 SDS

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