1185083-95-7Relevant academic research and scientific papers
Diels-alder cycloaddition strategy for kinetic resolution of chiral pyrazolidinones
Sibi, Mukund P.,Kawashima, Keisuke,Stanley, Levi M.
supporting information; experimental part, p. 3894 - 3897 (2009/12/05)
A rare example of the application of a catalytic, enantioselective Diels-Alder cycloaddition to affect a kinetic resolution has been developed. Chiral pyrazolidinones are resolved with high selectivity through a process that utilizes a relay of stereochemical information from a permanent chiral center to a fluxional chiral center to enhance the inherent selectivity of the chiral Lewis acid catalyst.
