1185190-81-1

Basic information

• Product Name: 4,6-dichloro-2-Methylnicotinonitrile
• Synonyms: 4,6-dichloro-2-Methylnicotinonitrile
• CAS NO: 1185190-81-1
• Molecular Formula: C7H4Cl2N2
• Molecular Weight: 187.02606
• EINECS: -0
• Mol File: 1185190-81-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,6-dichloro-2-Methylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-2-Methylnicotinonitrile(1185190-81-1)
• EPA Substance Registry System: 4,6-dichloro-2-Methylnicotinonitrile(1185190-81-1)

Safety Data

• Hazardous Substances Data: 1185190-81-1(Hazardous Substances Data)

Upstream product

• 64169-92-2 4-hydroxy-2-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile 

Downstream Products

• 1589541-46-7 (R)-1-(4-chloro-5-cyano-6-methylpyridin-2-yl)-3-(1-phenylethyl)urea 
• 1589539-44-5 (R)-N-(4-methyl-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide 
• 1589541-59-2 (R)-1-(3-amino-4-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589536-79-7 (R)-N-(4-(methoxymethyl)-6-(3-(1-phenylethyl)ureido)-1H-pyrazolo[4,3-c]pyridin-3-yl)acetamide 
• 1589536-78-6 (R)-1-(3-(ethylamino)-4-(methoxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589536-76-4 (R)-1-(3-amino-4-(methoxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589541-06-9 (R)-1-(4-chloro-5-cyano-6-(methoxymethyl)pyridin-2-yl)-3-(1-phenylethyl)urea 
• 1589536-75-3 (R)-1-(3-amino-4-(hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-(1-phenylethyl)urea 
• 1589541-04-7 (R)-(4-chloro-3-cyano-6-(3-(1-phenylethyl)ureido)pyridin-2-yl)methyl acetate 

Relevant articles and documents

INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Synthesis and biological evaluation of C-5 methyl substituted 4-arylthio and 4-aryloxy-3-iodopyridin-2(1H)-one type anti-HIV agents

A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin- 2(1H)-ones has been synthesized as new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones (14 and 15). Biological studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, compounds 93 and 99 are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains.