118520-73-3

Basic information

• Product Name: 2-(4-bromophenylethynyl)benzoic acid methyl ester
• Synonyms: 2-(4-bromophenylethynyl)benzoic acid methyl ester
• CAS NO: 118520-73-3
• Molecular Weight: 315.166
• Mol File: 118520-73-3.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenylethynyl)benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenylethynyl)benzoic acid methyl ester(118520-73-3)
• EPA Substance Registry System: 2-(4-bromophenylethynyl)benzoic acid methyl ester(118520-73-3)

Safety Data

• Hazardous Substances Data: 118520-73-3(Hazardous Substances Data)

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 118520-70-0 1-copper(I) (4-bromophenyl)ethyne 

Downstream Products

• 130818-31-4 (Z)-2-(4-bromostyryl)benzoic acid 
• 1190831-57-2 (Z)-N-amino-3-(4-bromobenzylidene)isoindolin-1-one 
• 1610626-69-1 (3Z)-3-(4-bromobenzylidene)-2-hydroxy-2,3-dihydro-1H-isoindol-1-one 
• 1560948-81-3 3-[4-(1-methoxy-1-methylethyl)phenyl]-2H-isoquinolin-1-one 
• 1560948-76-6 3-[4-(1-fluoro-1-methylethyl)phenyl]-2H-isoquinolin-1-one 
• 1560948-66-4 3-(4-hydroxymethylphenyl)-2H-isoquinolin-1-one 
• 1560948-55-1 3-[4-(1-hydroxy-1-methylethyl)phenyl]-2H-isoquinolin-1-one 
• 1560948-53-9 4-(1-oxo-1,2-dihydroisoquinolin-3-yl)benzoic acid methyl ester 
• 124394-21-4 3-(4-bromophenyl)isoquinolin-1(2H)-one 
• 1452790-31-6 C₁₉H₁₅BrO₃ 
• 118520-92-6 4-Acetyl-3-(p-bromophenyl)-isocoumarin 
• 118520-88-0 3-(4-bromophenyl)-1H-2-benzopyran-1-one 
• 118520-89-1 4-Iodo-3-(p-bromophenyl)-isocoumarin 
• 118520-90-4 4-Bromo-3-(p-bromophenyl)-isocoumarin 

Relevant articles and documents

Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.

Metal-Free Synthesis of 4-Chloroisocoumarins by TMSCl-Catalyzed NCS-Induced Chlorinative Annulation of 2-Alkynylaryloate Esters

4-Chloroisocoumarins can be conveniently prepared from 2-alkynylaryloate esters via the activation of alkynes by electrophilic chlorine, generated in situ from N-chlorosuccinimide (NCS) in the presence of 10 mol % trimethylsilyl chloride (TMSCl), which leads to 6-endo-dig-selective chlorinative annulation to give the desired products in moderate to quantitative yields. The procedure employs readily available reagents and can be conveniently carried out on a wide scope of substrates under mild conditions (0 °C to rt). Furthermore, the reaction is scalable for gram-scale preparation of 4-chloroisocoumarins. Additionally, 4-bromo- and 4-iodoisocoumarins can be prepared in moderate to good yields by replacing NCS with N-bromosuccinimide (NBS) and N-iodosuccinimide (NIS), respectively.

(AZA-)ISOQUINOLINONE DERIVATIVES

Compounds of the formula (I), in which R1, X, Y and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Base-catalyzed heterocyclization of 2-(R-ethynyl)benzohydroxamic acids

Sonogashira alkynylation of methyl 2-iodobenzoate with terminal acetylenes gave a series of methyl 2-(alk-1-yn-1-yl)benzoates which reacted with hydroxylamine in boiling methanol to produce five- or six-membered N-hydroxy lactams, 3-R-methylidene-2-hydroxy-2,3-dihydroisoindol-1-ones or 3-R-isoquinolin-1(2H)-ones, depending on the acetylenic substituent nature.

Palladium(II)-catalyzed tandem annulation reaction of o-alkynylbenzoates with methyl vinyl ketone for the synthesis of isocoumarins

A palladium(II)-catalyzed highly regioselective tandem reactions of o-alkynylbenzoates with methyl vinyl ketone for the synthesis of isocoumarins was developed. It is a convenient, mild and environmentally benign reaction with moderate to high yield. The

Tuning selectivity of anionic cyclizations: Competition between 5-exo and 6-endo-dig closures of hydrazides of o-acetylenyl benzoic acids and based-catalyzed fragmentation/recyclization of the initial 5-exo-dig products

(Chemical Equation Presented) Depending on the reaction conditions and the nature of substituents at the triple bond, anionic cyclizations of hydrazides of o-acetylenyl benzoic acids can be selectively directed along three alternative paths, each of which

Transmission of Polar Effects. Part 21. Alkaline Hydrolysis of the 2'- and 4'-substituted 2-Methoxycarbonyldiphenylacetylenes and (Z)-2'- and -4'- Substituted 2-Methoxycarbonylstilbenes and the Ionisation and Esterification, with Diazodiphenylmethane of t

The rate coefficients for the alkaline hydrolysis of a series of 2'- and 4'-substituted 2-methoxycarbonyldiphenylacetylenes and (Z)-2-methoxycarbonylstilbenes have been determined in 70percent (v/v) dimethyl sulphoxide-water at both 30.0 and 50.0 deg C an