124394-21-4

Upstream product

• 2170-09-4 N,2-dimethylbenzamide 
• 623-00-7 4-bromobenzenecarbonitrile 
• 4001-73-4 2-Bromobenzamide 
• 99-90-1 para-bromoacetophenone 
• 3930-83-4 o-iodobenzamide 
• 5467-74-3 4-Bromophenylboronic acid 
• 5597-04-6 2-cyanomethylbenzoic acid methyl ester 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 118520-88-0 3-(4-bromophenyl)-1H-2-benzopyran-1-one 
• 118520-73-3 2-(4-bromophenylethynyl)benzoic acid methyl ester 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 124394-15-6 2-((4-bromophenyl)ethynyl)benzamide 

Downstream Products

• 194292-27-8 1-chloro-3-(4-bromophenyl)isoquinoline 
• 1560948-55-1 3-[4-(1-hydroxy-1-methylethyl)phenyl]-2H-isoquinolin-1-one 
• 1560948-66-4 3-(4-hydroxymethylphenyl)-2H-isoquinolin-1-one 
• 1560948-76-6 3-[4-(1-fluoro-1-methylethyl)phenyl]-2H-isoquinolin-1-one 
• 1560948-81-3 3-[4-(1-methoxy-1-methylethyl)phenyl]-2H-isoquinolin-1-one 
• 1560948-53-9 4-(1-oxo-1,2-dihydroisoquinolin-3-yl)benzoic acid methyl ester 

Relevant academic research and scientific papers

Nickel-Catalyzed Tandem Reaction of Functionalized Arylacetonitriles with Arylboronic Acids in 2-MeTHF: Eco-Friendly Synthesis of Aminoisoquinolines and Isoquinolones

The first example of the nickel-catalyzed tandem addition/cyclization of 2-(cyanomethyl)benzonitriles with arylboronic acids in 2-MeTHF has been developed, which provides the facile synthesis of aminoisoquinolines with good functional group tolerance under mild conditions. This chemistry has also been successfully applied to the synthesis of isoquinolones by the tandem reaction of methyl 2-(cyanomethyl)benzoates with arylboronic acids. The use of the bio-based and green solvent 2-MeTHF as the reaction medium makes the synthesis process environmentally benign. The synthetic utility of this chemistry is also indicated by the synthesis of biologically active molecules.

Tandem addition/cyclization for access to isoquinolines and isoquinolones via catalytic carbopalladation of nitriles

The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally di

A simple access to N-(un)substituted isoquinolin-1(2H)-ones: Unusual formation of regioisomeric isoquinolin-1(4H)-ones

A ligand/additive/Pd-free Cu-mediated coupling/cyclization strategy afforded the first practical, one-pot and general approach towards synthesis of N-(un)substituted isoquinolin-1(2H)-ones. Both the catalyst and the solvent used are recyclable. The use of the Cu reagent in excess led to the unusual formation of regioisomeric and uncommon isoquinolin-1(4H)-ones. This journal is the Partner Organisations 2014.

Copper-catalyzed selective synthesis of isoindolin-1-ones and isoquinolin-1-ones from the three-component coupling of 2-halobenzoic acid, alkynylcarboxylic acid and ammonium acetate

Isoindolin-1-ones and isoquinolin-1-ones were selectively synthesized from the reaction of 2-halobenzoic acid, arylalkynylcarboxylic acid and ammonium acetate (NH4OAc) in the presence of cesium carbonate (Cs2CO3) and a copper catalyst. Conducting the reaction under one-pot conditions provided isoindolin-1-ones in good yields. Changing the addition sequence of ammonium acetate after all reagents had reacted at 120 °C for 6 h selectively produced isoquinolin-1-ones. A variety of arylalkynylcarboxylic acids produced the corresponding isoindolin-1-ones and isoquinolin-1-ones in good yields.

(AZA-)ISOQUINOLINONE DERIVATIVES

Compounds of the formula (I), in which R1, X, Y and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Synthesis of functionalized isoquinolin-1(2H)-ones by copper-catalyzed α-arylation of ketones with 2-halobenzamides

Copper is key: A concise route to isoquinolin-1(2H)-ones from simple and readily available starting materials is provided by an efficient copper-catalyzed annulation of ketones with 2-halobenzamides. The method is applicable to a wide range of ketones con

Synthesis of new 3-arylisoquinolinamines: Effect on topoisomerase I inhibition and cytotoxicity

To investigate the structure-activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I-DNA complex was also performed.

Fused pyridine derivatives

The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.

Organopalladium mediated synthesis of isocarbostyrils

3-Substituted-isocarbostyrils have been synthesised by the cyclisation of 2-alkynylbenzamides with palladium reagents.