118527-07-4Relevant academic research and scientific papers
Attempted Synthesis of Some α-Halolactones Fused in Bicycloheptanes
Hashem, Md. Abul
, p. 424 - 429 (2007/10/02)
For the synthesis of the lactones A, B and C, compounds 4a, 4b, 10a and 10b were synthesized by dihalocyclopropanation and epoxidation of the dienes 1 and 7. 4a and 10a on hydrolysis give the corresponding diols 11 and 12.Treatment of 10a and 10b with BuLi/CO2 at -90 deg C gives the α-halocarboxylic acids 13a and 13b respectively.Both 13a and 13b on hydrolysis with 2N H2SO4 in acetone afford polymeric material, from which no pure product could be isolated.A dihydroxy-α-chlorocyclopropyl ester (17) has been synthesized from 1 but no lactone could be isolated.
