118527-76-7

Upstream product

• 121945-03-7 (5-Trimethylsilanyl-3-trimethylsilanyloxy-cyclohex-2-enylmethyl)-benzene 
• 56917-71-6 5-trimethylsilyl-2-cyclohexanone 
• 56917-70-5 5-(trimethylsilyl)cyclohex-3-enone 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 118527-83-6 (4R,6S)-4-Benzyl-6-trimethylsilanyl-oxepan-2-one 
• 93468-27-0 5-benzyl-2-cyclohexen-1-one 
• 118527-97-2 3-Benzyl-5-oxo-hexanoic acid methyl ester 
• 118527-90-5 3-Benzyl-hex-5-enoic acid methyl ester 
• 22530-98-9 4-benzyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

Silver(I)-catalyzed ring-contractive rearrangement: A new entry to 5-alkylidene-2-cyclopentenones

A novel silver(I)-catalyzed ring-contractive rearrangement of 5-substituted 6-diazo-2-cyclohexenones has been developed, providing a new and efficient access to 5-alkylidene-2-cyclopentenones. The AgOTf-catalyzed reaction proceeds through metal-carbenoid formation followed by endocyclic allyl [1,2] migration with excellent stereoselectivity and broad substrate scope.

SYNTHESIS OF (+)-α-CURCUMENE, (+)-CURCUMONE AND (-)-METHYL CITRONELLATE STARTING FROM OPTICALLY PURE 5-TRIMETHYLSILYL-2-CYCLOHEXENONE

1,4-addition of Grignard reagents in the presence of chlorotrimethylsilane to 5-trimethylsilyl-2-cyclohexanone (1) proceeded in a highly diastereoselective manner to give trans adducts in high yields. (+)-α-Curcumene, (+)-curcumone and (-)-methyl citronellate were synthesized starting from optically pure 1.

3-Substituted-γ-butyrolactones from 5-Trimethylsilyl-2-cyclohexenone. Synthesis of (-)-Enterolactone

1,4-Adducts of 5-trimethylsilyl-2-cyclohexenone (1) with Grignard reagents were converted to various hexanoate derivatives and γ-butyrolactones.Starting from optically pure 1, (-)-enterolactone (Factor X) was synthesized.