1185302-72-0Relevant articles and documents
Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs
Redko, Boris,Albeck, Amnon,Gellerman, Gary
, p. 2188 - 2191 (2013/01/15)
A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.