5434-20-8Relevant academic research and scientific papers
A dicopper complex chemiluminescence probe for the determination of thiols in the extracts of murine P388 lymphocytic leukemia cell
Zhang, Xiaoru,Zhou, Huanran,Ding, Caifeng,Zhang, Shusheng
, p. 5624 - 5626 (2009)
A chemiluminescence (CL) probe of peroxidase-like dicopper complex (Cu 2L2) for the determination of glutathione (GSH) and related cellular thiols was developed for the first time.
Chemiluminescence determination of trimetazidine via inducing the aggregation of gold nanoparticles
Li, Jiao,Quan, Jie,Du, Jianxiu,Liu, Mei
, p. 33 - 37 (2013)
A simple, rapid and sensitive chemiluminescence (CL) method combined with flow injection analysis was developed for the determination of trimetazidine. Trimetazidine was found to significantly increase the CL signal arising from N-bromosuccinimide-luminol reaction in the presence of gold nanoparticles. The enhanced CL intensity was proportional to trimetazidine concentration in the range of 0.01-5.0 μg/mL, with a limit of detection (3sb) of 6.7 ng/mL. The relative standard deviation was 2.8% for 11 repetitive measurements of 0.1 μg/mL trimetazidine solution. The practicality of the method was evaluated by determining trimetazidine in pharmaceutical formulations and in spiked human serum samples. Moreover, the possible CL reaction mechanism was also discussed.
Mesoporous material-based manipulation of the enzyme-like activity of CoFe2O4 nanoparticles
Fan, Yingwei,Shi, Wenbing,Zhang, Xiaodan,Huang, Yuming
, p. 2482 - 2486 (2014)
Mesoporous material supported CoFe2O4 magnetic nanoparticles possess unique peroxidase/oxidase-like activity, and react with luminol to yield a novel chemiluminescence without the need of H 2O2. Their oxidase-like activity shows pH and support dependence, and could be reversibly controlled by their pH. This offers a new method for manipulating the enzyme-like activity of nanoparticles.
Enzyme-Loaded Hemin/G-Quadruplex-Modified ZIF-90 Metal–Organic Framework Nanoparticles: Bioreactor Nanozymes for the Cascaded Oxidation of N-hydroxy-l-arginine and Sensing Applications
Chen, Chaochao,O'Hagan, Michael P.,Ouyang, Yu,Vázquez-González, Margarita,Wang, Zhanhui,Willner, Itamar
, (2022/01/19)
Biocatalytic cascades are challenging to operate in homogeneous solution, where diffusional mass transport hinders efficient communication between the reactive components. There is great interest in developing devices to perform such transformations in co
ISOINDOLE DERIVATIVE
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Paragraph 0226, (2021/02/25)
Disclosed is a compound of formula (I) and a stereoisomer thereof: wherein R1, R2, R3 and R4 are as defined in the present disclosure.
Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides
Schilling, Waldemar,Zhang, Yu,Riemer, Daniel,Das, Shoubhik
supporting information, p. 390 - 395 (2019/12/15)
Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N-protected and protection-free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst.
Synthesis method of methyl 2-acetyl-6-aminobenzoate
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Paragraph 0055; 0057; 0058; 0069; 0071; 0072, (2020/05/01)
The invention provides a synthesis method of methyl 2-acetyl-6-aminobenzoate. The target product methyl 2-acetyl-6-aminobenzoate is prepared from cheap and easily available 3-nitrophthalic acid through a six-step reaction. The synthesis method has the characteristics of easily available raw materials, short route, high yield, easiness in operation, small environmental pollution and the like, and is suitable for large-scale industrial production.
Palladium Supported on Carbon Nanoglobules as a Promising Catalyst for Selective Hydrogenation of Nitroarenes
Mironenko,Belskaya,Stepanova,Gulyaeva,Trenikhin,Likholobov
, p. 888 - 900 (2019/11/11)
The catalysts 1?wt% palladium supported on carbon nanoglobules (CNGs) were shown to be highly active in the liquid-phase hydrogenation of various nitroarenes and provided nearly 100% selectivity to aromatic amines at complete conversion under mild conditions (323?K, 0.5?MPa, 1?h). The catalytic activity (in terms of turnover frequency and substrate conversion) and selectivity depend on the kind of CNGs support, catalyst preparation method and the reaction conditions (solvent nature). The Pd/CNGs catalyst can be repeatedly used while maintaining the same catalytic performance. The excellent performances of Pd/CNGs catalysts can be due to the globular morphology of the supports as well as the absence of micropores and pronounced surface defects. Graphic Abstract: [Figure not available: see fulltext.]
METHODS FOR THE TREATMENT OF OBESITY USING APREMILAST
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Paragraph 0079, (2019/05/22)
Methods of treating, managing or preventing obesity and overweight are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.
APREMILAST FOR THE TREATMENT OF A LIVER DISEASE OR A LIVER FUNCTION ABNORMALITY
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Paragraph 0098, (2019/09/15)
Methods of treating, managing or preventing liver disease are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.
