1185502-97-9

Usage

Uses

Used in Pharmaceutical Industry:
Aprepitant is used as an antiemetic medication for the prevention of nausea and vomiting caused by chemotherapy and other medical treatments. It is employed to block the action of substance P, which is involved in the regulation of vomiting, thereby providing relief to patients undergoing treatments that can cause severe nausea and vomiting.
Used in Oncology:
Aprepitant is used as a supportive care medication in oncology to manage the distressing side effects of chemotherapy, improving the quality of life for cancer patients. It is often used in combination with other antiemetic drugs to provide effective and long-lasting relief from chemotherapy-induced nausea and vomiting, ensuring that patients can better tolerate their treatments and maintain their overall well-being during cancer therapy.

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Relevant academic research and scientific papers

Synthesis of the major isomers of Aprepitant and Fosaprepitant

The synthesis of two isomers of Aprepitant (APT) and three isomers of Fosaprepitant (FPT), crucial components for quality control in manufacturing, is described. Herein, three chiral centers in the isomers of Aprepitant are established in high yield by in

Synthesis of all enantiomerically pure diastereomers of aprepitant

Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and X-ray crystallographic analysis were achieved. Copyrigh

PREPARATION OF MORPHOLINE DERIVATIVES

This invention relates to processes and intermediates for the stereoselective morpholine derivatives. The invention in particular allows the stereoselective preparation of the drugs aprepitant and fosaprepitant.