118561-70-9

Usage

Uses

Used in Chemical Synthesis:
2,6-DIMETHYL-3,5-DINITROBENZOIC ACID is used as a key intermediate in the production of dyes, pigments, and pharmaceuticals. Its chemical properties allow it to be a versatile building block in the synthesis of a variety of organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2,6-DIMETHYL-3,5-DINITROBENZOIC ACID is utilized as a precursor for the development of new drugs. Its unique structure and reactivity make it suitable for the creation of medicinal compounds with specific therapeutic properties.
Used in Dye and Pigment Manufacturing:
2,6-DIMETHYL-3,5-DINITROBENZOIC ACID is employed as a starting material in the manufacturing of dyes and pigments. Its ability to form stable and vibrant color compounds makes it an essential component in this industry.
Used as a Reagent in Chemical Reactions:
Due to its stability and reactivity, 2,6-DIMETHYL-3,5-DINITROBENZOIC ACID is also used as a reagent in various chemical reactions. It aids in the transformation of other compounds and contributes to the advancement of chemical research and development.

Upstream product

• 21113-43-9 1,2,3-trimethyl-4,6-dinitrobenzene 
• 632-46-2 2,6-dimethylbenzoic acid 

Downstream Products

• 1105057-34-8 2,6-dimethyl-3,5-dinitrobenzoic anhydride 

Relevant academic research and scientific papers

2,6-Dimethyl-4-nitrobenzoic anhydride (DMNBA): An effective coupling reagent for the synthesis of carboxylic esters and lactones

Various carboxylic esters are obtained at room temperature in excellent yields with high chemoselectivities from nearly equimolar amounts of carboxylic acids and alcohols using 2,6-dimethyl-4-nitrobenzoic anhydride with triethylamine by the promotion of 4-(dimethylamino)pyridine. The efficiency of the esterification is compared to those of other dehydrations using substituted benzoic anhydrides as coupling reagents. This method was successfully applied to the synthesis of threo-aleuritic acid lactone and the desired 17-membered ring compound was prepared in high yield at room temperature from the corresponding free trihydroxycarboxylic acid using 2,6-dimethyl-4-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine.

The Nitration of 3,4,5,6-Tetramethylbenzene-1,2-dicarbonitrile, 2,3,5,6-Tetramethylbenzonitrile, 1,2,3-Trimethyl-4,6-dinitrobenzene and 1,2,4,5-Tetramethyl-3,6-dinitrobenzene. Methyl Migrations Following ipso-Substitution

Nitration of 3,4,5,6-tetramethylbenzene-1,2-dicarbonitrile (1a) gives epimeric pairs of dinitro ketones (6a) and (7a), and hydroxy ketones (9) and (10), in addition to the benzyl nitrate (4) and phthalide (5).Nitration of 2,3,5,6-tetramethylbenzonitrile (11) gives the epimeric dinitro ketones (15) and (16), in addition to the nitrobenzonitrile (12) and the nitrophthalide (13).Nitration of 1,2,3-trimethyl-4,6-dinitrobenzene (17) gives dimethylpropanedioic acid (23), the dinitrobenzoic acid (24), and the hydroxy dienone (25).Nitration of 1,2,4,5-tetramethyl-3,6-dinitrobenzene (18) gives dimethylpropanedioic acid (23), the dinitrobenzoic acid (26), and the nitro dicarboxylic acid (27).The formation of compounds (6a), (7a), (9), (10), (15), (16), (23) and (27) all involve methyl migrations following nitronium ion attack ipso to the migrating methyl group.X-Ray structure determinations are reported for compounds (6a), (9) and (15).

Process for the production of nitro derivatives of aromatic compounds

Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.