1185745-51-0

Basic information

• Product Name: (2S,4R)-ethyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate
• Synonyms: (2S,4R)-ethyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate
• CAS NO: 1185745-51-0
• Molecular Weight: 613.4
• Mol File: 1185745-51-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,4R)-ethyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-ethyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate(1185745-51-0)
• EPA Substance Registry System: (2S,4R)-ethyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate(1185745-51-0)

Safety Data

• Hazardous Substances Data: 1185745-51-0(Hazardous Substances Data)

Upstream product

• 112981-69-8 3,5-bis(trifluoromethyl)phenylmagnesium bromide 
• 19887-35-5 (2S,4R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-ethyl ester 
• 1185745-50-9 (2S,4R)-ethyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-(tetrahydro-2H-pyran-2-yloxy)pyrrolidine-1-carboxylate 

Downstream Products

• 1185745-38-3 (3R,5S)-5-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)pyrrolidin-3-ol 
• 1352751-07-5 (2S,4R)-2-(bis(3,5-bis(trifluoromethyl)phenyl)(trimethylsiloxy)methyl)-4-(4-phenyloxy)pyrrolidine 

Relevant articles and documents

Highly enantioselective aldol reaction of acetaldehyde and isatins only with 4-hydroxydiarylprolinol as catalyst: concise stereoselective synthesis of (R)-convolutamydines B and E, (-)-donaxaridine and (R)-chimonamidine

A highly enantioselective aldol reaction of acetaldehyde and a wide scope of isatins has been presented only using readily available 4-hydroxydiarylprolinol as catalyst, affording various desired 3-substituted 3-hydroxyindolin-2-one adducts with moderate to high yield (up to 95%) and good enantioselectivities (up to 98% ee). This method not only represents an example of concise stereoselective synthesis of enantiopure (R)-convolutamydines B and E, but also firstly exhibits expedient asymmetric synthesis optically active (-)-donaxaridine and (R)-chimonamidine.