1185877-05-7

Upstream product

• 58520-50-6 C₂₈H₂₂F₂N₂O₂ 
• 50802-45-4 C₂₈H₂₀F₄N₂O 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 125448-81-9 1,2-Bis-(4-fluoro-phenyl)-N,N'-bis-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-ethane-1,2-diamine 
• 50648-93-6 d,l-1,2-diamino-1,2-bis(4-fluorophenyl)ethane 

Relevant academic research and scientific papers

Chemoselective Photoredox Synthesis of Unprotected Primary Amines Using Ammonia

Unprotected α-amino carbon radicals are produced as novel intermediates via a transformation that merges acid-promoted N-H imine generation and chemoselective photocatalytic single-electron reduction. Coupling ammonia and aldehydes/ketones allows the generation of primary amines under mild conditions without the need for protecting groups. The key intermediate can be efficiently transformed into primary (di)amines by a formal dimerization, reductive amination via hydrogen atom transfer, and arylation through radical-radical coupling.

Heterocyclic compounds as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: 1 wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer''s disease, etc.

Tumor inhibiting platinum-(II) complexes. Part I: synthesis

The synthesis of the diastereomeric 1,2-bis(2-, 3-, and 4-fluorophenyl)ethylenediamines 4-6, 10-12 from meso-1,2-bis(2-hydroxyphenyl)ethylenediamine and 2-, 3-, and 4-fluorobenzaldehyde by a diaza-Cope-rearrangement and their conversion into the 1,2-bis(