118603-65-9Relevant academic research and scientific papers
Improvement method for preparation technology of 3-(2-ethyl-2,2-dimethyl hydrazinyl) ethyl propionate iodate bulk drug
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Paragraph 0009; 0011-0012; 0014-0015; 0017, (2019/07/01)
The invention relates to an improvement method for a preparation technology of a 3-(2-ethyl-2,2-dimethyl hydrazinyl) ethyl propionate iodate bulk drug being an important antiarrhythmic drug. In orderto overcome the defects of raw material and intermediate instability, many reaction by-products and the like of a 1,1-dimethylhydrazine and ethyl acrylate addition reaction, in a process from the addition reaction to an alkylation reaction, special measures for treating impurities, controlling the impurities, passivating the impurities and the like are adopted for obtaining a high-purity 3-(2-ethyl-2,2-dimethyl hydrazinyl) ethyl propionate iodate bulk drug crystal; various impurity residue varieties of a final target compound and the step of macroporous resin purification in industrial production are avoided; all impurity sources are controlled and eliminated; and the advantages of commercial scale production, cost reduction, equipment simplicity and the like are realized.
Ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate salts to treat arrhythmia
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, (2008/06/13)
The present invention relates to the art of organic chemistry. The novel compounds - ethyl-3-(2-ethyl-2,2-dimethylhydrazinium)-propionate salts have the general formula: STR1 wherein X is Cl, Br, I. The compounds of the present invention possess an antiarrhythmic effect.
