118604-66-3

Upstream product

• 85385-06-4 2,6-dimethylphenyl-1'-methyl-2'-methoxyethyl-imine 
• 74-88-4 methyl iodide 
• 132034-50-5 (Z)-2,6-dimethylphenyl-1'-methyl-2'-methoxyethyl-imine 
• 57646-33-0 methyl (2R)-2-[(2,6-dimethylphenyl)amino]propanoate 

Relevant academic research and scientific papers

Iridium-imine and -amine complexes relevant to the (S)-metolachlor process: Structures, exchange kinetics, and C-H activation by IrI causing racemization

Iridium complexes of DMA-imine [2,6-dimethylphenyl-1′-methyl- 2′-methoxyethylimine, 1a) and (R)-DMA-amine [(1′R)-2,6- dimethylphenyl-1′-methyl-2′-methoxyethylamine, 2a] that are relevant to the catalytic imine hydrogenation step of the Syngenta (S)-Metola

Chiral poisoning of rac-diop iridium complexes in the catalytic enantioselective hydrogenation of imines

Dimeric Ir(III) complexes [Ir(P-P)HI2]2 (P-P = enantiopure bisphosphine) have previously been shown to be efficient catalysts for the enantioselective hydrogenation of imines. In the present study we have prepared the analogues using

Asymmetric hydrogenation of imines catalysed by carboxylato(diphosphine)iridium(III) complexes

The synthesis of three new families of monomeric carboxylato(diphosphine)iridium(III) complexes is described (e.g. diphosphine = diop, binap, bdpp). Some of these complexes catalyse the asymmetric hydrogenation of prochiral imines to amines in good activi

Method for preparing chiral amine by asymmetric hydrogenation of imine

The invention discloses a method for preparing chiral amine by asymmetric hydrogenation of imine. Chiral ferrocene phosphine-diformamidine imine reacts with a metal iridium precursor in situ to prepare a complex which is used as a catalyst, and asymmetric

Chiral organic catalysts for the stereoselective reduction of carbon-nitrogen double bonds for the preparation of enantiomerically enriched amines

The invention relates to compounds of general formula (I): wherein R1-R7 are as defined in the description for use as catalysts in the stereoselective reduction of imines in the presence of trichlorosilane as reducing agent.

Chiral Lewis base promoted trichlorosilane reduction of ketimines. An enantioselective organocatalytic synthesis of chiral amines

The reduction of the carbon-nitrogen double bond is an important transformation. Here we report our studies on a family of chiral organic catalysts able to promote the stereoselective reduction of ketimines with trichlorosilane. The very cheap, metal-free catalysts were easily prepared in one step from commercially available products, namely a chiral aminoalcohol and picolinic acid derivatives. The catalyst structure was extensively modified in a study that allowed to identify an extremely active species, able to promote the reduction on a large variety of substrates with high efficiency (up to 95% ee). A three component methodology has been also developed, where the enantiomerically enriched amine was isolated after performing the reaction by mixing a ketone and an amine in the presence of trichlorosilane and the catalyst. Its synthetic potentiality was demonstrated by employing the present metal-free catalytic procedure in the preparation of (S)-metolachlor, a potent and widely used herbicide.