118618-46-5

Upstream product

• 64-17-5 ethanol 
• 118618-37-4 2--propionic acid 
• 535-11-5 Ethyl 2-bromopropionate 
• 78547-13-4 2-(p-amino-phenoxy)-propionic acid 
• 767-00-0 4-cyanophenol 
• 28059-75-8 ethyl 2-(4-aminophenoxy)propionate 
• 118618-36-3 2--propionic acid 
• 149505-94-2 tert-butyl (4-hydroxybenzyl)carbamate 
• 49786-89-2 p-<1-(ethoxycarbonyl)-ethyloxy>-phenylacetonitrile 

Downstream Products

• 142335-63-5 1-benzyl>-pyrrole 
• 1421688-79-0 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(2-cyanophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-78-9 ethyl 2-(4-(((S)-1-((S)-2-amino(4-?uorophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-77-8 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(4-(trfluoromethyl)phenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-76-7 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(4-cyanophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-75-6 ethyl 2-(4-((S)-1-((S)-2-amino-3-(4-methoxyphenyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-74-5 ethyl 2-(4-(((S)-1-((S)-2-amino-3-p-tolylpropanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-73-4 ethyl 2-(4-(((S)-1-((S)-2-amino-3-phenylpropanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-82-5 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(3-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-81-4 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(3-cyanophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 
• 1421688-80-3 ethyl 2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)methyl)phenoxy)propanoate 

Relevant academic research and scientific papers

Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes. The treatment of MetS requires multiple pharmaceutical agents leading to complex polypharmacy. Multi-ta

Discovering Novel α-aminoacyl-Containing Proline Derivatives with Potent and Selective Inhibitory Activity Against Dipeptidyl Peptidase IV: Design, Synthesis, Biological Evaluation, and Molecular Modeling

On the basis of the enzyme-binding features of known potent inhibitors of dipeptidyl peptidase IV, novel α-aminoacyl-containing proline analogs (8Aa-8Ak, 8Ba-8Bj, 8Ca-8Ck, and 8Da-8Di) with the S configuration were designed, synthesized, and their activit

Potent and selective proline derived dipeptidyl peptidase IV inhibitors

In-house screening of the Merck sample collection identified proline derived homophenylalanine 3 as a DPP-IV inhibitor with modest potency (DPP-IV IC50 = 1.9 μM). Optimization of 3 led to compound 37, which is among the most potent and selectiv

Structure-activity studies on a 1,2,3-triazole derivative, a potent in vitro inhibitor of prostaglandin synthesis: The role of the heterocyclic ring

This paper reports further structural modifications concerning the 1,2,3- triazole ring of the compound A, an effective in vitro inhibitor of prostaglandin synthesis. The introduction of different heterocyclic rings provided further information about of t