1186196-18-8Relevant articles and documents
Synthesis and evaluation of 3″- and 4″-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000
Raju, Ravinder,Castillo, Bernard F.,Richardson, Stewart K.,Thakur, Meena,Severins, Ryan,Kronenberg, Mitchell,Howell, Amy R.
, p. 4122 - 4125 (2009)
Four 3″- and 4″-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4″-fluoro analog led to the production of significant levels of IL-2.