205371-71-7Relevant articles and documents
Synthesis of a 2 -Deoxy-β-GalCer
Thakur, Meena S.,Khurana, Archana,Kronenberg, Mitchell,Howell, Amy R.
, p. 10090 - 10102 (2014/08/05)
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2''-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.