118630-19-6Relevant articles and documents
5-(1-Piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents
Meyer,Tomcufcik,Chan,Haug
, p. 593 - 597 (2007/10/02)
A series of 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines was synthesized and screened for antihypertensive and diuretic activity in spontaneously hypertensive rats (SHR). One compound, 5-[4-[(3-chlorophenyl)methyl]-1-piperazinyl]-1H-1,2,4-triazol-3-amine (8), was selected to define the mechanism of its antihypertensive activity. Studies in SHR suggest ganglionic blocking activity. Short-lived antihypertensive activity was observed in conscious renal hypertensive dogs.