1186332-08-0Relevant academic research and scientific papers
BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF
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Page/Page column 46-47, (2009/10/21)
Compounds of formula A: Formula (1) pharmaceutically acceptable salts thereof are described, which selectively inhibit Raf kinase activity and are useful for treating disorders mediated by Raf kinases.
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors
Di Grandi, Martin J.,Berger, Dan M.,Hopper, Darrin W.,Zhang, Chunchun,Dutia, Minu,Dunnick, Alejandro L.,Torres, Nancy,Levin, Jeremy I.,Diamantidis, George,Zapf, Christoph W.,Bloom, Jonathan D.,Hu, YongBo,Powell, Dennis,Wojciechowicz, Donald,Collins, Karen,Frommer, Eileen
body text, p. 6957 - 6961 (2010/06/19)
A novel series of pyrazolo[1,5-a]pyrimidines bearing a 3-hydroxyphenyl group at C(3) and substituted tropanes at C(7) have been identified as potent B-Raf inhibitors. Exploration of alternative functional groups as a replacement for the C(3) phenol demons
