1339838-72-0

Upstream product

• 692-51-3 (E)-trimethyl(3,3,3-trifluoroprop-1-en-1-yl)silane 
• 459-57-4 4-fluorobenzaldehyde 
• 887144-97-0 Togni's reagent 
• 2314-97-8 iodotrifluoromethane 
• 3798-61-6 1-(4-fluorophenyl)prop-2-yn-1-ol 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 71783-52-3 2-(4-fluorophenyl)acrylic acid 
• 50415-66-2 methyl 2-(4-fluorophenyl)acrylate 
• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 147164-48-5 1-(4-fluorophenyl)ethenyl acetate 
• 405-99-2 para-fluorostyrene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1186338-51-1 (2,2-difluorocyclopropyl)(4-fluorophenyl)methanone 
• 51594-59-3 1-(4-fluorophenyl)-2-propen-1-one 

Relevant academic research and scientific papers

Synthesis of β-Trifluoromethylated Ketones from Propargylic Alcohols by Visible Light Photoredox Catalysis

Regioselective trifluoromethylation at a remote position represents an important challenge in the development of biologically active molecules and functional materials. A practical method to access β-trifluoromethyl ketones from readily available propargylic alcohols by visible light photocatalysis has been developed. Trifluoromethylation of propargylic alcohols with CF3I in the presence of Ru(bpy)3Cl2 as the photocatalyst followed by double-bond migration/keto-enol tautomerization provides β-trifluoromethyl ketones as the final product. β-Trifluoromethyl ketones are synthesized from readily available propargylic alcohols by visible light photocatalysis. Trifluoromethylation followed by double-bond migration/keto-enol tautomerization provides β-trifluoromethyl ketones as the final product.

Base-Promoted Double-Bond-Migration/Hydrolysis/Isomerization of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoromethanesulfonates: A Metal-Free Approach to β-Trifluoromethyl Ketones

A method for the synthesis of β-trifluoromethyl ketones promoted by a base is described. In the presence of DBU, 1-aryl-4,4,4-trifluoromethylbutanones with various functional groups were obtained through the reaction of 4-aryl-1,1,1-trifluorobut-2-en-2-yl

Synthesis of β-CF 3 Ketones through Copper/Silver Cocatalyzed Oxidative Coupling of Enol Acetates with ICH 2 CF 3

A simple method for the synthesis of β-CF 3 ketones through copper/silver cocatalyzed oxidative coupling of enol acetates with ICH 2 CF 3 has been developed. Enol acetates were chosen as the source of carbonyl group, giving the β-CF 3 ketones in moderate yields. Control experiments imply that a radical process maybe involved in this reaction.

Preparation method of 1-aryl-4,4,4-trifluoro-1-butanone compound

The invention relates to a preparation method of a 1-aryl-4,4,4-trifluoro-1-butanone compound and belongs to the field of compound preparation. The preparation method is characterized by comprising the following steps of by taking trifluoromethyl-substituted enol sulfonate as a compound shown in a general formula II as a raw material, synthesizing 1-aryl-4,4,4-trifluoro-1-butanone as a compound shown in a general formula I: the formula l is shown in the description. The method provided by the invention provides a method which is convenient and is low in cost for synthesis of the 1-aryl-4,4,4-trifluoro-1-butanone compound and avoids using an expensive metal catalyst reagent.

Free-Radical-Promoted Copper-Catalyzed Decarboxylative Alkylation of α,β-Unsaturated Carboxylic Acids with ICH2CF3 and Its Analogues

A novel and efficient free-radical-promoted copper-catalyzed decarboxylative alkylation of α,β-unsaturated carboxylic acids with ICH2CF3 and its analogues has been developed. This methodology provides a convenient access to the synthesis of allylic trifluoromethyl and β-CF3 ketone containing compounds as well as other biologically useful fluorinated molecules and materials.

Copper/Silver Cocatalyzed Oxidative Coupling of Vinylarenes with ICH2CF3 or ICH2CHF2 Leading to β-CF3/CHF2-Substituted Ketones

A novel copper/silver cocatalyzed oxidative coupling of vinylarenes with ICH2CF3 or ICH2CHF2 through a radical process has been developed. The transformation provides an attractive approach to β-CF3/CHF2-substituted ketones, with the advantages of easily available starting materials and operational simplicity.

Efficient synthesis of β-CF3/SCF3-substituted carbonyls via copper-catalyzed electrophilic ring-opening cross-coupling of cyclopropanols

The first copper-catalyzed ring-opening electrophilic trifluoromethylation and trifluoromethylthiolation of cyclopropanols to form Csp3-CF3 and Csp3-SCF3 bonds have been realized. These transformations are effic

Method for preparing of carbonyl compound

The present invention relates to a method for preparing a carbonyl compound. More specifically, the present invention relates to a method for preparing a carbonyl compound where a trifluoromethyl group is introduced at the andbeta;-position thereof, thereby simplifying the reaction in a smooth condition under visual light and a photocatalyst and achieving a high yield as well as allowing a carbonyl compound having high economical efficiency to be prepared.COPYRIGHT KIPO 2015

Boron-trihalide-promoted regioselective ring-opening reactions of gem-difluorocyclopropyl ketones

Boron trihalide-promoted ring-opening reactions of gem-difluorocyclopropyl ketones to give the corresponding β-trifluoromethyl ketones and β-halodifluoromethyl ketones were described. It was found that boron trihalides act as both Lewis acids and nucleophiles and the proximal bond prefers to cleave in this transformation.

Oxidative 3,3,3-trifluoropropylation of arylaldehydes

A reaction between (E)-trimethyl(3,3,3-trifluoroprop-1-en-1-yl)silane (1) and arylaldehydes 2 was triggered by fluoride anions to afford aryl 3,3,3-trifluoropropyl ketones 3 in moderate to good yield. A mechanistic study of this reaction indicated that it occurred via an allyl alkoxide (4). A subsequent 1,3-proton shift of the benzylic proton of 4 forms 3. This reaction involves oxidative 3,3,3-trifluoropropylation of an arylaldehyde to afford 4,4,4-trifluoro-1-arylbutan-1-one.