1186338-53-3

Upstream product

• 1186338-35-1 C₁₅H₁₅ClF₂O₂ 
• 120801-75-4 trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate 
• 160388-09-0 1-(3-chlorophenyl)prop-2-en-1-one 
• 99-02-5 3'-Chloroacetophenone 

Downstream Products

• 1461634-35-4 (3-chlorophenyl)(5-fluoro-2-methyl-1H-pyrrol-3-yl)methanone 
• 1343294-14-3 1-(3- chlorophenyl)-4,4,4-trifluorobutan-1-one 
• 1529771-24-1 4-chloro-1-(3-chlorophenyl)-4,4-difluorobutan-1-one 
• 1529771-34-3 4-bromo-1-(3-chlorophenyl)-4,4-difluorobutan-1-one 

Relevant academic research and scientific papers

Boron-trihalide-promoted regioselective ring-opening reactions of gem-difluorocyclopropyl ketones

Boron trihalide-promoted ring-opening reactions of gem-difluorocyclopropyl ketones to give the corresponding β-trifluoromethyl ketones and β-halodifluoromethyl ketones were described. It was found that boron trihalides act as both Lewis acids and nucleophiles and the proximal bond prefers to cleave in this transformation.

A novel reaction of gem-difluorocyclopropyl ketones with nitriles leading to 2-fluoropyrroles

The CF3SO3H-promoted ring opening of gem-difluorocyclopropyl ketones prefers to undergo proximal bond cleavage and the subsequent cyclization with nitriles occurred smoothly to give 2-fluoropyrroles.

Reaction of difluorocarbene with propargyl esters and efficient synthesis of difluorocyclopropyl ketones

Difluorocarbene generated from FSO2CF2CO2SiMe3 (TFDA) at 120 °C could reacted with terminal alkynes having an ester group at the α position to the triple bond. Difluorocyclopropenes were further converted to difluorocyclopropyl ketones under alkaline condition. Mechanism for the conversion was studied.