1186408-09-2

Basic information

• Product Name: C₁₆H₂₃FN₂O₄S
• CAS NO: 1186408-09-2
• Molecular Weight: 358.434
• Mol File: 1186408-09-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₃FN₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₃FN₂O₄S(1186408-09-2)
• EPA Substance Registry System: C₁₆H₂₃FN₂O₄S(1186408-09-2)

Safety Data

• Hazardous Substances Data: 1186408-09-2(Hazardous Substances Data)

Upstream product

• 701-27-9 3-fluorobenzene-1-sulfonyl chloride 
• 119020-01-8 (S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of β-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV

Modifications of DPP-4 inhibitor 5, that was discovered by structure based design, are described and structure-activity relationships discussed. With analogue 7k one of the most potent non-covalent inhibitors of DPP-4 reported to date (IC50 = 0.38 nM) was discovered. X-ray structure of inhibitor 7k bound to DPP-4 revealed a hydrogen bonding interaction with Q553. First successful efforts in balancing overall properties, as demonstrated by improved metabolic stability, highlight the potential of this series.